Six New Polyketide Decalin Compounds from Mangrove Endophytic Fungus Penicillium aurantiogriseum 328#

被引：25

作者：

Ma, Yanhong ^{[1
]}

Li, Jing ^{[2
,3
]}

Huang, Meixiang ^{[1
]}

Liu, Lan ^{[2
,4
]}

Wang, Jun ^{[1
]}

Lin, Yongcheng ^{[3
,4
,5
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Sch Marine Sci, Guangzhou 510006, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Dept Educ Guangdong Prov, Key Lab Funct Mol Ocean Microorganisms, Guangzhou 510080, Guangdong, Peoples R China

[4] South China Sea Bioresource Exploitat & Utilizat, Guangzhou 510006, Guangdong, Peoples R China

[5] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

来源：

MARINE DRUGS | 2015年 / 13卷 / 10期

基金：

中国国家自然科学基金;

关键词：

mangrove endophytic fungi; Penicillium aurantiogriseum; secondary metabolites; polyketide decalin derivative; ABSOLUTE-CONFIGURATION; MARINE; METABOLITES;

D O I：

10.3390/md13106306

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six new compounds with polyketide decalin ring, peaurantiogriseols A-F (1-6), along with two known compounds, aspermytin A (7), 1-propanone,3-hydroxy-1-(1,2,4a,5,6,7,8,8a-octahydro-2,5-dihydroxy-1,2,6-trimethyl-1-naphthalenyl) (8), were isolated from the fermentation products of mangrove endophytic fungus Penicillium aurantiogriseum 328#. Their structures were elucidated based on their structure analysis. The absolute configurations of compounds 1 and 2 were determined by H-1 NMR analysis of their Mosher esters; the absolute configurations of 3-6 were determined by using theoretical calculations of electronic circular dichroism (ECD). Compounds 1-8 showed low inhibitory activity against human aldose reductase, no activity of inducing neurite outgrowth, nor antimicrobial activity.

引用

页码：6306 / 6318

页数：13

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