Genetics of Obsessive-Compulsive Disorder and Related Disorders

被引：47
作者：
Browne, Heidi A. [1 ,2 ]
Gair, Shannon L. [1 ]
Scharf, Jeremiah M. [3 ,4 ]
Grice, Dorothy E. [1 ,2 ]
机构：
[1] Icahn Sch Med Mt Sinai, Dept Psychiat, Div Tics OCD & Related Disorders, OCD & Related Disorders Program, New York, NY 10029 USA
[2] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA
[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Movement Disorders Unit,Dept Neurol, Boston, MA 02114 USA
[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Psychiat & Neurodev Genet Unit,Dept Psychiat, Boston, MA 02114 USA
来源：
PSYCHIATRIC CLINICS OF NORTH AMERICA | 2014年 / 37卷 / 03期
关键词：
OCD; Genetics; Heritability; Twin study; Familial recurrence; GWAS; Candidate gene; Model system; GENOME-WIDE ASSOCIATION; COPY NUMBER VARIANTS; LA-TOURETTES-SYNDROME; SPECTRUM DISORDERS; COMMON VARIANTS; ENVIRONMENTAL-INFLUENCES; SLITRK1; VAR321; RISK-FACTORS; FAMILY; TWIN;
D O I：
10.1016/j.psc.2014.06.002
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Twin and family studies support a significant genetic contribution to obsessive-compulsive disorder (OCD) and related disorders, such as chronic tic disorders, trichotillomania, skin-picking disorder, body dysmorphic disorder, and hoarding disorder. Recently, population-based studies and novel laboratory-based methods have confirmed substantial heritability in OCD. Genome-wide association studies and candidate gene association studies have provided information on specific gene variations that may be involved in the pathobiology of OCD, though a substantial portion of the genetic risk architecture remains unknown.
引用
收藏
页码：319 / +
页数：18
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