Effectiveness of a pharmacist-led structured group-based intervention in improving medication adherence and glycaemic control among type 2 diabetes mellitus patients: A randomized controlled trial

被引：16

作者：

Ting, Chuo Yew ^{[1
,2
]}

Adruce, Shahren Ahmad Zaidi ^{[1
,3
]}

Lim, Chien Joo ^{[4
]}

Abd Jabar, Abu Hassan Alshaari ^{[5
]}

Ting, Rachel Sing-Kiat ^{[6
]}

Ting, Hiram ^{[7
,8
]}

Osman, Nor Anizah ^{[2
]}

Ngau, Esther ^{[9
]}

Talin, Benodict Apok ^{[10
]}

Muhammad, Munira ^{[11
]}

Loo, Shing Chyi ^{[10
]}

Lim, Su Ee ^{[2
]}

Hassali, Mohamed Azmi ^{[12
]}

机构：

[1] Univ Malaysia Sarawak, Inst Borneo Studies, Sarawak, Malaysia

[2] Minitry Hlth, Pharm Practice & Dev Div, Sarawak State Hlth Dept Sarawak, Putrajaya, Malaysia

[3] Univ Malaysia Sarawak, Fac Cognit Sci & Human Dev, Sarawak, Malaysia

[4] Tan Tock Seng Hosp, Clin Res & Innovat Off, Singapore, Singapore

[5] Minist Hlth, Pharmaceut Serv Div, Sarawak State Hlth Dept Sarawak, Putrajaya, Malaysia

[6] Monash Univ, Jeffrey Cheah Sch Med & Hlth Sci, Subang Jaya, Selangor, Malaysia

[7] Sarawak Res Soc, Sarawak, Malaysia

[8] UCSI Univ, Fac Hospitality & Tourism Management, Kuala Lumpur, Malaysia

[9] Minist Hlth, Petra Jaya Hlth Clin, Pharm Dept, Petra Jaya, Kuching, Malaysia

[10] Minist Hlth, Pharm Enforcement Div, Sarawak State Hlth Dept Sarawak, Putrajaya, Malaysia

[11] Minist Hlth, Pharmaceut Serv Div, Putrajaya, Malaysia

[12] Univ Sains Malaysia, Sch Pharmaceut Sci, Social & Adm Pharm, George Town, Malaysia

来源：

RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY | 2021年 / 17卷 / 02期

关键词：

Type 2 Diabetes Mellitus; Medication adherence; Pharmacist-led; Structured group-based intervention; Malaysia; SELF-MANAGEMENT EDUCATION; QUALITY-OF-LIFE; HYPOGLYCEMIC MEDICATION; PLANNED BEHAVIOR; SKILLS MODEL; OLDER-ADULTS; 12; TIPS; ASSOCIATION; VALIDATION; NUTRITION;

D O I：

10.1016/j.sapharm.2020.03.026

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: A pharmacist-led structured group-based intervention (MEDIHEALTH) was formulated to improve medication adherence among Malay type 2 diabetes mellitus (T2DM) patients in the Malaysian state of Sarawak. Objectives: The objective of this study was to examine the effectiveness of MEDIHEALTH and its mechanism of impact for improving medication adherence and the glycated haemoglobin (HbA1c) level. Methods: A two group and parallel randomised controlled trial with a twelve months follow-up period was conducted at two primary health clinics in Malaysia that were surrounded by Malay communities. Malay T2DM patients whose HbA1c was > 7% and total score on the Self-Efficacy for Appropriate Medication Use Scale (SEAMS) was < 26 were recruited and parallelly randomised to the MEDIHEALTH or usual care (control) groups. The extended theory of planned behaviour was employed to test the mechanism of impact. Repeated measure analysis of variance was used to assess the difference in the estimated marginal mean of the SEAMS scores and HbA1c level between the intervention and control groups at different times. Results: A total of 142 participants were recruited and randomised; three from the intervention group and eight from the control group withdrew before receiving any treatment. Hence, 68 participants in the intervention group and 63 in the control group were included for analyses. The MEDIHEALTH group had a significantly greater increase in the SEAMS score compared to the control group (p < 0.001) at one, three, six and twelve months post-intervention. There was also a significantly greater reduction in HbA1c in the MEDIHEALTH compared to the control group at one, three, six and twelve months post-intervention (p < 0.001). These improvements were mediated by enhancements in perceived behavioural control and knowledge about medications. Conclusions: The MEDIHEALTH may improve medication adherence and glycaemic control among Malay T2DM patients.

引用

页码：344 / 355

页数：12

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