Synthesis, Crystal Structure and DNA Interaction of N-(Benzimidazol-2-ylmethyl)-5-chlorosalicylideneimine

被引：0

作者：

Cheng Jian-Ping ^{[1
,2
]}

Lin Qiu-Yue ^{[1
,2
]}

Zhu Wen-Zhong ^{[1
,2
]}

Wang Yun-Yun ^{[1
]}

Xian Hui-Duo ^{[1
]}

机构：

[1] Zhejiang Normal Univ, Zhejiang Key Lab React Chem Solid Surfaces, Jinhua 321004, Peoples R China

[2] Zhejiang Normal Univ, Coll Chem & Life Sci, Jinhua 321004, Peoples R China

来源：

CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2009年 / 28卷 / 02期

关键词：

crystal structure; 2-aminomethylbenzimidazole; 5-chlorosalicylaldehyde; DNA; DEOXYRIBONUCLEIC-ACID; ANTHRYL PROBE; FLUORESCENCE; DERIVATIVES; BINDING; BASES;

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The title compound, N-(benzimidazol-2-ylmethyl)-5-chlorosalicylidenei mine, has been synthesized and characterized by X-ray single-crystal diffraction. It crystallizes in the monoclinic system, space group P2(1)/n, with a = 8.3765(2), b = 18.1398(4), c = 9.4764(3) angstrom, beta = 112.141(2)degrees, V = 1333.74(6) angstrom(3), M-r = 285.73, Z = 4, D-c = 1.423 g/cm(3), F(000) = 592, mu = 0.285 mm(-1), the final R = 0.0538 and wR = 0.1456 for 1917 observed reflections with I > 2 sigma(I). The fluorescence quenching of the title compound by DNA with Stern-Volmer constant of 2.8x10(4) M-1 indicates that it binds to double-stranded DNA in a partial intercalation mode.

引用

页码：235 / 239

页数：5

共 13 条

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[2] STUDIES ON INTERACTION OF ANTHRACYCLINE ANTIBIOTICS AND DEOXYRIBONUCLEIC-ACID - EQUILIBRIUM BINDING-STUDIES ON INTERACTION OF DAUNOMYCIN WITH DEOXYRIBONUCLEIC-ACID [J].