Curcumin Ameliorates Streptozotocin-Induced Heart Injury in Rats

被引：37

作者：

Abo-Salem, Osama M. ^{[1
,2
]}

Harisa, Gamaleldin I. ^{[3
,4
]}

Ali, Tarek M. ^{[1
,5
]}

El-Sayed, El-Sayed M. ^{[2
]}

Abou-Elnour, Fatma M. ^{[6
]}

机构：

[1] Taif Univ, Coll Appl Med Sci, Dept Lab Sci & Clin Technol, At Taif, Saudi Arabia

[2] Al Azhar Univ, Fac Pharm Boys, Dept Pharmacol & Toxicol, Cairo, Egypt

[3] King Saud Univ, Dept Pharmaceut, Coll Pharm, Kayyali Chair Pharmaceut Ind, Riyadh 11451, Saudi Arabia

[4] Al Azhar Univ, Dept Biochem, Fac Pharm Boys, Cairo, Egypt

[5] Beni Suef Univ, Fac Med, Dept Physiol, Bani Suwayf, Egypt

[6] Minist Hlth, Clin Pathol Dept, Blood Bank & Labs Adm, At Taif, Saudi Arabia

来源：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2014年 / 28卷 / 06期

关键词：

STZ; Diabetes; Heart Injury; Curcumin; Oxidative Stress; Cytokines; KAPPA-B ACTIVATION; OXIDATIVE STRESS; DIABETIC CARDIOMYOPATHY; ANTIOXIDANT DEFENSE; LIPID-PEROXIDATION; NITRIC-OXIDE; CHEMOPREVENTION; MECHANISMS; ANALOGS; LONGA;

D O I：

10.1002/jbt.21562

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Heart failure (HF) is one of diabetic complications. This work was designed to investigate the possible modulatory effect of curcumin against streptozotocin-induced diabetes and consequently HF in rats. Rats were divided into control, vehicle-treated, curcumin-treated, diabetic-untreated, diabetic curcumin-treated, and diabetic glibenclamide-treated groups. Animal treatment was started 5 days after induction of diabetes and extended for 6 weeks. Diabetic rats showed significant increase in serum glucose, triglycerides, total cholesterol, low-density lipoprotein-cholesterol, very low density lipoprotein-cholesterol, nitric oxide, lactate dehydrogenase, cardiac malondialdehyde, plasma levels of interleukin-6, and tumor necrosis factor-alpha, and also showed marked decrease in serum high-density lipoprotein-cholesterol, cardiac reduced glutathione, and cardiac antioxidant enzymes (catalase, superoxide dismutase, and glutathione-S-transferase). However, curcumin or glibenclamide treatment significantly mitigated such changes. In conclusion, curcumin has a beneficial therapeutic effect in diabetes-induced HF, an effect that might be attributable to its antioxidant and suppressive activity on cytokines.

引用

页码：263 / 270

页数：8

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