Visual Isotope Effects: Demonstrating the Primary Kinetic Isotope Effect in the Chromium(VI) Oxidation of 2-Propanol-d8 and Methanol-d4

被引：9
|
作者：
Iskenderian-Epps, Wendy S. [1 ]
Soltis, Chloe [2 ]
O'Leary, Daniel J. [1 ]
机构：
[1] Pomona Coll, Dept Chem, Claremont, CA 91711 USA
[2] Vivian Webb High Sch, Claremont, CA 91711 USA
来源：
JOURNAL OF CHEMICAL EDUCATION | 2013年 / 90卷 / 08期
关键词：
First-Year Undergraduate/General; Second-Year Undergraduate; Upper-Division Undergraduate; Demonstrations; Organic Chemistry; Alcohols; Oxidation/Reduction; Isotope Effect;
D O I：
10.1021/ed300628n
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The kinetic isotope effect in the Cr(VI) oxidation of commercially available 2-propanol-d(8) or methanol-d(4) is readily demonstrated using 4 mL reaction vials projected with a document camera. For the case of 2-propanol, the demonstration reveals how a rate-determining step can be identified with an isotopically labeled compound, providing students with an example of how mechanistic evidence is experimentally determined. The 2-propanol oxidation demonstration has been documented in a YouTube video, which also discusses the relevant chemistry.
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页码：1044 / 1047
页数：4
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