Secondary metabolites from the mangrove sediment-derived fungus Penicillium pinophilum SCAU037

被引：25

作者：

He, Fei ^{[1
]}

Li, Xiaobao ^{[2
]}

Yu, Jin-Hai ^{[1
]}

Zhang, Xiaoyong ^{[3
]}

Nong, Xuhua ^{[2
]}

Chen, Guangying ^{[2
]}

Zhu, Kongkai ^{[1
]}

Wang, Yin-Yin ^{[1
]}

Bao, Jie ^{[1
]}

Zhang, Hua ^{[1
]}

机构：

[1] Univ Jinan, Sch Biol Sci & Technol, 336 West Rd Nan Xinzhuang, Jinan 250022, Shandong, Peoples R China

[2] Hainan Normal Univ, Key Lab Trop Med Resource Chem, Minist Educ, 99 South Rd Longkun Rd, Haikou 571158, Hainan, Peoples R China

[3] South China Agr Univ, Coll Marine Sci, 483 Wushan Rd, Guangzhou 510642, Guangdong, Peoples R China

来源：

FITOTERAPIA | 2019年 / 136卷

基金：

中国国家自然科学基金;

关键词：

Mangrove sediment; Penicillium pinophilum; Funicone analogues; Antibacterial activity; alpha-Glucosidase inhibitory activity; GLUCOSIDASE INHIBITORY-ACTIVITY; FAMILY DNA-POLYMERASES; VERMISTATIN DERIVATIVES; ENDOPHYTIC FUNGUS; BIOSYNTHESIS; AZAPHILONE; FUNICONE;

D O I：

10.1016/j.fitote.2019.104177

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new funicone derivatives, pinophilones A-E (1a/1b and 2-4), along with 18 biosynthetically related known analogues (5-22), were obtained from the culture of a mangrove sediment-derived fungus Penicillium pinophilum SCAU037. Their structures were established by analysis of 1D/2D NMR and MS data, while the absolute configurations of the new compounds were determined by ECD calculation based on time-dependent density functional theory (TD-DFT). The dihydrofuran moiety in 1a and 1b was first reported for funicone derivatives. Compound 22 exhibited antibacterial activity against Mycobacterium smegmatis and Staphylococcus aureus with IC50 of 23.5 and 2.6 mu M, respectively, while 16,18 and 22 showed significant alpha-glucosidase inhibitory activity with IC50 of 51.9, 78.4 and 33.8 mu M, respectively.

引用

页数：6

共 34 条

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