Recent advances in cutaneous angiogenesis

被引:39
作者
Bhushan, M [1 ]
Young, HS
Brenchley, PEC
Griffiths, CEM
机构
[1] Univ Manchester, Hope Hosp, Sch Med, Dermatol Ctr, Salford M6 8HD, Lancs, England
[2] Univ Manchester, Manchester Royal Infirm, Dept Med, Manchester M13 9WL, Lancs, England
关键词
angiogenesis; angiopoietins; therapy; thrombospondin; vascular endothelial growth factor;
D O I
10.1046/j.1365-2133.2002.05003.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
An understanding of the molecular basis of angiogenesis is key to the appreciation of many of the advances made in the field of neovascularization over the past two decades. The sequence of events involved in angiogenesis includes: (i) increased vascular permeability and leakage; (ii) degradation of basement membrane; (iii) endothelial cell proliferation and migration through the surrounding extracellular matrix; and (iv) maturation and stabilization of the newly formed vessel bed. This review provides an update on the molecular basis of such pathways in the skin, with particular emphasis on the endothelial cell-specific vascular endothelial growth factor and angiopoietins as modulators of angiogenesis that can be targeted in therapy of cutaneous disease.
引用
收藏
页码:418 / 425
页数:8
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