Montmorillonite intercalated with vitamin B1 as drug carrier

被引：158
作者：
Joshi, Ghanshyam V. [1 ]
Patel, Hasmukh A. [1 ]
Kevadiya, Bhavesh D. [1 ]
Bajaj, Hari C. [1 ]
机构：
[1] CSIR, Cent Salt & Marine Chem Res Inst, Discipline Inorgan Mat & Catalysis, Bhavnagar 364002, Gujarat, India
来源：
APPLIED CLAY SCIENCE | 2009年 / 45卷 / 04期
关键词：
Montmorillonite; Thiamine hydrochloride; Intercalation; In vitro release; RELEASE BEHAVIOR; CATIONIC DRUGS; ADSORPTION; DELIVERY; BENTONITE; ACID;
D O I：
10.1016/j.clay.2009.06.001
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Vitamin B-1 (thiamine hydrochloride, VB1) intercalated into montmorillonite (MMT), which was characterized by X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FT-IR), and thermo gravimetric analysis (TGA). The adsorption of VB1 on MMT increased with increase in reaction temperature. The adsorption isotherms were fitted by the Langmuir model. About 34 and 64% of the intercalated VB1 was released within 10 h, in simulated gastric fluid (pH 1.2) and simulated intestinal fluid (pH 7.4) respectively at 37 +/- 0.5 degrees C The release profile of VB1 followed the Higuchi kinetic model and the diffusion-controlled mechanism. During in vitro release experiments VB1 was released from MMT-VB1 steadily as a function of pH. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：248 / 253
页数：6
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