Highly selective colorimetric sensor for cysteine and homocysteine based on azo derivatives

被引：100

作者：

Zhang, Dengqing

Zhang, Meng

Liu, Zhiqiang

Yu, Mengxiao

Li, Fuyou ^{[1
]}

Yi, Tao

Huang, Chunhui

机构：

[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

[2] Fudan Univ, Adv Mat Lab, Shanghai 200433, Peoples R China

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 39期

基金：

中国国家自然科学基金;

关键词：

colorimetric detection; cysteine; homocysteine;

D O I：

10.1016/j.tetlet.2006.07.080

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple colorimetric method for the determination of cysteine and homocysteine has been developed. The reaction of the azo dyes containing an aldehyde group with cysteine or homocysteine afforded very stable derivatives thiazolidines or thiazinanes under neutral pH conditions. The method is selective and sensitive for cysteine and homocysteine detection without the interference of other amino acids. Importantly, the recognition of Cys and Hcy could be observed by naked eyes. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：7093 / 7096

页数：4

共 52 条

[1] Achieving large color changes in response to the presence of amino acids:: A molecular sensing ensemble with selectivity for aspartate [J].