Non-small-cell lung cancers: a heterogeneous set of diseases

被引：1502

作者：

Chen, Zhao ^{[1
]}

Fillmore, Christine M. ^{[2
,3
,4
]}

Hammerman, Peter S. ^{[1
]}

Kim, Carla F. ^{[2
,3
,4
]}

Wong, Kwok-Kin ^{[1
,5
,6
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Boston Childrens Hosp, Stem Cell Program, Boston, MA 02115 USA

[3] Harvard Stem Cell Inst, Cambridge, MA 02138 USA

[4] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[6] Dana Farber Canc Inst, Belfer Inst Appl Canc Sci, Boston, MA 02115 USA

来源：

NATURE REVIEWS CANCER | 2014年 / 14卷 / 08期

关键词：

BRONCHIOALVEOLAR STEM-CELLS; ONCOGENIC K-RAS; TUMOR PROGRESSION; MOUSE MODEL; SELECTIVE-INHIBITION; THERAPEUTIC TARGET; CLINICAL-RESPONSE; CAUSES RESISTANCE; INITIATING CELLS; DEHYDROGENASE;

D O I：

10.1038/nrc3775

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Non-small-cell lung cancers (NSCLCs), the most common lung cancers, are known to have diverse pathological features. During the past decade, in-depth analyses of lung cancer genomes and signalling pathways have further defined NSCLCs as a group of distinct diseases with genetic and cellular heterogeneity. Consequently, an impressive list of potential therapeutic targets was unveiled, drastically altering the clinical evaluation and treatment of patients. Many targeted therapies have been developed with compelling clinical proofs of concept; however, treatment responses are typically short-lived. Further studies of the tumour microenvironment have uncovered new possible avenues to control this deadly disease, including immunotherapy.

引用

页码：535 / 546

页数：12

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