Phosphinoferrocenylaminophosphines as novel and practical ligands for asymmetric catalysis

被引：128

作者：

Boaz, NW ^{[1
]}

Debenham, SD ^{[1
]}

Mackenzie, EB ^{[1
]}

Large, SE ^{[1
]}

机构：

[1] Eastman Chem Co, Res Labs, Kingsport, TN 37662 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 14期

关键词：

D O I：

10.1021/ol0261736

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A new series of ligands with a novel phosphine-aminophosphine ligation design as depicted in structure 1 has been prepared on a ferrocenylethyl backbone. These BoPhoz ligands of structure 2 have afforded exceedingly high activity and enantioselectivity in the rhodium-catalyzed asymmetric hydrogenation of dehydro-alpha-amino acid derivatives, itaconic acids, and alpha-ketoesters. These air-stable ligands are readily prepared from cost-effective and non-pyrophoric intermediates.

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页码：2421 / 2424

页数：4

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