Design, Synthesis, Molecular Docking, and ADME Studies of Some New 2-Substituted 1-(6H-indolo[2,3-b]quinoxalin-6-yl)ethan-1-ones as Antitubercular Agents

A new series of 2-substituted 1-(6H-indolo[2,3-b]quinoxalin-6-yl)ethan-1-ones ( 4a-1) was synthesized and evaluated for antitubercular activity against Mycobacterium tuberculosis H37 Rv strains (ATCC27294) by Microplate Alamar blue assay method using isoniazid and rifampicin as reference drugs. The structures of all synthesized compounds 4a-1 were confirmed by spectroscopic (infrared, H-1 NMR, C-13 NMR, and mass) and elemental analysis data. The synthesized compounds were also screened for their binding analysis and pharmacokinetic properties using glide and QikProp tool of Maestro. Among all the compounds, compound 4e and 4g exhibited excellent antitubercular activity against M tuberculosis H37 Rv strains. All tested compounds showed excellent binding affinity towards target protein.