Efficacy of afoxolaner against Ixodes scapularis ticks in dogs

被引：20

作者：

Mitchell, Elizabeth B. ^{[1
]}

McCall, John W. ^{[2
]}

Chester, S. Theodore ^{[1
]}

Larsen, Diane ^{[1
]}

机构：

[1] Merial Ltd, Duluth, GA 30096 USA

[2] TRS Labs Inc, Athens, GA USA

来源：

VETERINARY PARASITOLOGY | 2014年 / 201卷 / 3-4期

关键词：

Afoxolaner; Dogs; Ixodes scapularis; Ticks; Oral; BORNE PATHOGENS; ONE HEALTH; SPOT-ON; CATS; INFESTATIONS; BIOLOGY; BIRDS; FLEA;

D O I：

10.1016/j.vetpar.2014.02.015

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Efficacy of afoxolaner, a novel isoxazoline insecticide/acaricide, against Ixodes scapularis was evaluated in a laboratory study. One day prior to treatment, beagle dogs (n = 16) were infested with 50 unfed wild adult ticks. Repeat infestations were performed weekly for four additional weeks. The number of live ticks remaining on each dog was determined 48 h after treatment and after each subsequent infestation. A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5 mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30. (C) 2014 The Authors. Published by Elsevier B.V.

引用

收藏

页码：223 / 225

页数：3

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