CoMut: visualizing integrated molecular information with comutation plots

被引:37
作者
Crowdis, Jett [1 ,2 ]
He, Meng Xiao [1 ,2 ,3 ]
Reardon, Brendan [1 ,2 ]
Van Allen, Eliezer M. [1 ,2 ]
机构
[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA
[2] Broad Inst Harvard & MIT, Canc Program, Cambridge, MA 02142 USA
[3] Grad Sch Arts & Sci, Harvard Grad Program Biophys, Boston, MA 02115 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
D O I
10.1093/bioinformatics/btaa554
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Motivation: Large-scale sequencing studies have created a need to succinctly visualize genomic characteristics of patient cohorts linked to widely variable phenotypic information. This is often done by visualizing the co-occurrence of variants with comutation plots. Current tools lack the ability to create highly customizable and publication quality comutation plots from arbitrary user data. Results: We developed CoMut, a stand-alone, object-oriented Python package that creates comutation plots from arbitrary input data, including categorical data, continuous data, bar graphs, side bar graphs and data that describes relationships between samples.
引用
收藏
页码:4348 / 4349
页数:2
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