Effects of alcohol and oxidative stress on liver pathology: The role of the mitochondrion

被引：85
作者：
Cahill, A
Cunningham, CC
Adachi, M
Ishii, H
Bailey, SM
Fromenty, B
Davies, A
机构：
[1] Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA
[2] Wake Forest Univ, Sch Med, Dept Biochem, Winston Salem, NC USA
[3] Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan
[4] Univ Alabama, Sch Publ Hlth, Dept Environm Hlth Sci, Birmingham, AL 35294 USA
[5] Hop Beaujon, INSERM, U481, Clichy, France
来源：
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 2002年 / 26卷 / 06期
关键词：
mitochondria; ethanol; oxidative stress; mitochondrial DNA; apoptosis;
D O I：
10.1111/j.1530-0277.2002.tb02621.x
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
This article represents the proceedings of a symposium at the 2001 Research Society on Alcoholism meeting in Montreal, Canada. The chairs were Alan Cahill and Carol C. Cunningham. The presentations were (1) Mitochondrial regulation of ethanol-induced hepatocyte apoptosis: possible involvement of proapoptotic Bcl-2 family protein Bax, by Masayuki Adachi and Hiromasa Ishii; (2) Effects of ethanol on mitochondrial reactive oxygen species production and oxidative protein modification, by Shannon M. Bailey; (3) Acute ethanol binges elicit widespread oxidative mitochondrial DNA damage and depletion: protective effects of antioxidants and inhibitors of ethanol metabolism, by Bernard Fromenty; and (4) Effects of chronic ethanol consumption upon hepatic mtDNA oxidative modification and depletion, by Alan Cahill and Adrian Davies.
引用
收藏
页码：907 / 915
页数：9
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