Frontal variant Alzheimer's disease: A reappraisal

被引：31
作者：
Larner, Andrew J. [1 ]
机构：
[1] Walton Ctr Neurol & Neurosurg, Cognit Funct Clin, Liverpool L9 7LJ, Merseyside, England
来源：
CLINICAL NEUROLOGY AND NEUROSURGERY | 2006年 / 108卷 / 07期
关键词：
ACE; Alzheimer's disease; dementia; diagnosis; frontal variant; frontotemporal dementia;
D O I：
10.1016/j.clineuro.2005.07.001
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Two cases of clinically diagnosed sporadic Alzheimer's disease with early and prominent behavioural features (social disinhibition, emotional blunting, stereotyped verbal utterances) sufficient to prompt an initial diagnosis of frontotemporal dementia are presented. It is suggested that the term "frontal variant AD" be used for this clinically defined phenotype, which has also been described in cases of inherited AD associated with certain presenilin-l gene mutations. This differs from previous usage of the term "frontal variant AD" to describe AD with predominant frontal lobe neuropathological change (although the clinical phenotype may reflect regional distribution of pathology), but parallels the clinical definition of visual agnosic, aphasic and apraxic presentations of AD. The proposed usage would also emphasise differential diagnosis. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：705 / 708
页数：4
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