Depression and Chronic Liver Diseases: Are There Shared Underlying Mechanisms?

被引：87

作者：

Huang, Xiaoqin ^{[1
]}

Liu, Xiaoyun ^{[1
]}

Yu, Yongqiang ^{[2
]}

机构：

[1] Anhui Med Univ, Affiliated Hosp 1, Dept Psychiat, Hefei, Peoples R China

[2] Anhui Med Univ, Affiliated Hosp 1, Dept Radiol, Hefei, Peoples R China

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2017年 / 10卷

基金：

中国国家自然科学基金;

关键词：

chronic liver disease (CLD); depression; hepatitis; non-alcoholic fatty liver disease (NAFLD); alcoholic liver disease (ALD); CHRONIC HEPATITIS-C; INTERFERON-ALPHA TREATMENT; NLRP3 INFLAMMASOME ACTIVATION; QUALITY-OF-LIFE; TYPE-2; DIABETES-MELLITUS; CHRONIC VIRAL-HEPATITIS; MILD STRESS MODEL; NONALCOHOLIC STEATOHEPATITIS; MAJOR DEPRESSION; RISK-FACTOR;

D O I：

10.3389/fnmol.2017.00134

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The occurrence of depression is higher in patients with chronic liver disease (CLD) than that in the general population. The mechanism described in previous studies mainly focused on inflammation and stress, which not only exists in CLD, but also emerges in common chronic diseases, leaving the specific mechanism unknown. This review was to summarize the prevalence and risk factors of depression in CLD including chronic hepatitis B, chronic hepatitis, alcoholic liver disease, and non-alcoholic fatty liver disease, and to point out the possible underlying mechanism of this potential link. Clarifying the origins of this common comorbidity (depression and CLD) may provide more information to understand both diseases.

引用

页数：11

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