Comprehensive spectral endoscopy of topically applied SERS nanoparticles in the rat esophagus

被引：30

作者：

Wang, Yu Winston ^{[1
]}

Khan, Altaz ^{[1
]}

Leigh, Steven Y. ^{[1
]}

Wang, Danni ^{[1
]}

Chen, Ye ^{[1
]}

Meza, Daphne ^{[1
]}

Liu, Jonathan T. C. ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Biomed Engn, Stony Brook, NY 11794 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2014年 / 5卷 / 09期

关键词：

ORGANIC-INORGANIC NANOPARTICLES; IN-VIVO; RAMAN; CANCER; DYSPLASIA; CARCINOMA; STRATEGY; SURVIVAL; TRENDS; TAGS;

D O I：

10.1364/BOE.5.002883

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The early detection and biological investigation of esophageal cancer would benefit from the development of advanced imaging techniques to screen for the molecular changes that precede and accompany the onset of cancer. Surface-enhanced Raman scattering (SERS) nanoparticles (NPs) have the potential to improve cancer detection and the investigation of cancer progression through the sensitive and multiplexed phenotyping of cell-surface biomarkers. Here, a miniature endoscope featuring rotational scanning and axial pull back has been developed for 2D spectral imaging of SERS NPs topically applied on the lumenal surface of the rat esophagus. Raman signals from low-pM concentrations of SERS NP mixtures are demultiplexed in real time to accurately calculate the concentration and ratio of the NPs. Ex vivo and in vivo experiments demonstrate the feasibility of topical application and imaging of multiplexed SERS NPs along the entire length of the rat esophagus. (C) 2014 Optical Society of America

引用

页码：2883 / 2895

页数：13

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