Hypolipidemic effect of the polysaccharides from Porphyra yezoensis

被引：46

作者：

Qian, Li ^{[1
]}

Zhou, Yan ^{[1
]}

Ma, Jian-Xin ^{[2
]}

机构：

[1] Second Peoples Hosp Lianyungang, Dept Microbiol Lab, Xinpu 222006, Peoples R China

[2] Second Peoples Hosp Lianyungang, Dept Radiotherapy, Xinpu 222006, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2014年 / 68卷

关键词：

Porphyra yezoensis; Hypolipidemic activity; Polysaccharides; ULTRASONIC DEGRADATION; ANTIOXIDANT ACTIVITY; PURIFICATION;

D O I：

10.1016/j.ijbiomac.2014.04.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study was performed to investigate the hypolipidemic effect of the polysaccharides extracted from Porphyra yezoensis. Male Sprague-Dawley rats were divided into three groups and orally treated with diets containing either high fat, P. yezoensis polysaccharides (PPs), or normal fat. Treatment of male Sprague-Dawley rats with PPs led not only to significant decreases in plasma triacylglycerol, total cholesterol, and plasma low-density lipoprotein cholesterol and an increase in plasma high-density lipoprotein cholesterol, but also to significant decreases in liver weight, triacylglycerol and cholesterol. Therefore, the results suggest that PPs had a high hypolipidemic activity and could be used as a potential therapeutic agent for hyperlipidemia. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：48 / 49

页数：2

共 13 条

[1]

FOLCH J, 1957, J BIOL CHEM, V226, P497

[2] In vivo protective effect of Porphyra yezoensis polysaccharide against carbon tetrachloride induced hepatotoxicity in mice [J].

Guo, Ting-ting ;

Xu, Hong-li ;

Zhang, Lu-xi ;

Zhang, Han-peng ;

Guo, Yi-feng ;

Gu, Jia-wen ;

He, Pei-min .

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 2007, 49 (02) :101-106

[3]

GUO TT, 2005, LETT BIOTECHNOL, V17, P359

[4]

He RongHai He RongHai, 2005, Transactions of the Chinese Society of Agricultural Engineering, V21, P165

[5] CHEMICAL AND PHYSICAL-CHEMICAL CHARACTERISTICS OF DIETARY-FIBERS FROM ULVA-LACTUCA (L) THURET AND ENTERMORPHA-COMPRESSA (L) GREV [J].

LAHAYE, M ;

JEGOU, D .

JOURNAL OF APPLIED PHYCOLOGY, 1993, 5 (02) :195-200

[6] Hypolipidemic effect of the polysaccharide from Pholiota nameko [J].

Li, Haiping ;

Zhang, Mingming ;

Ma, Guiji .

NUTRITION, 2010, 26 (05) :556-562

[7]

Nancy L.K., 1982, J DAIRY SCI, V65, P2274

[8]

Suetsuna K, 1998, J MAR BIOTECHNOL, V6, P163

[9] Hypolipidemic activity of the polysaccharides from Enteromorpha prolifera [J].

Teng, Zhaolin ;

Qian, Li ;

Zhou, Yan .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2013, 62 :254-256

[10]

Zhang LX, 2011, J MAR SCI TECH-TAIW, V19, P377

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