Effect of farnesol on Candida dubliniensis biofilm formation and fluconazole resistance

被引：105

作者：

Jabra-Rizk, Mary Ann

Shirtliff, Mark

James, Cathy

Meiller, Timothy

机构：

[1] Univ Maryland, Sch Dent, Dept Diagnost Sci & Pathol, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Dent, Dept Pathol, Baltimore, MD 21201 USA

[3] Univ Maryland, Sch Dent, Dept Biomed Sci, Baltimore, MD 21201 USA

[4] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

来源：

FEMS YEAST RESEARCH | 2006年 / 6卷 / 07期

关键词：

farnesol; fluconazole resistance; biofilm; Candida dubliniensis; Candida albicans;

D O I：

10.1111/j.1567-1364.2006.00121.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Candida dubliniensis and Candida albicans are dimorphic fungal species with a number of pathogenic capabilities, including biofilm formation, systemic infection and development of fluconazole resistance. In this study, the ability of farnesol to disrupt these virulence capabilities was investigated. Biofilm assessment and susceptibility studies indicated antifungal and antibiofilm properties for farnesol on both species with a disruptive effect on the cell membrane. Synergy testing of farnesol and fluconazole in resistant strains resulted in reversal of fluconazole resistance, indicating a potential application for farnesol as an adjuvant therapeutic agent.

引用

页码：1063 / 1073

页数：11

共 63 条

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