Bronsted Acid-Catalyzed Propargylation/Cycloisomerization Tandem Reaction: One-Pot Synthesis of Substituted Oxazoles from Propargylic Alcohols and Amides

被引：140

作者：

Pan, Ying-ming

Zheng, Fei-jian

Lin, Hai-xin

Zhan, Zhuang-ping ^{[1
]}

机构：

[1] Xiamen Univ, Dept Chem, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 08期

关键词：

FECL3-CATALYZED NUCLEOPHILIC-SUBSTITUTION; STRAIGHTFORWARD SYNTHESIS; EFFICIENT SYNTHESIS; CYCLIZATION; ISOCYANIDES; ALDEHYDES; ACETATES;

D O I：

10.1021/jo8027533

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient one-pot propargylation/cycloisomerization tandem process has been developed for the synthesis of substituted oxazole derivatives from propargylic alcohols and amides with use of p-toluenesulfonic acid monohydrate (PTSA) as a bifunctional catalyst. This method provides a rapid and efficient access to substituted oxazoles.

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页码：3148 / 3151

页数：4

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