Antibiotics given subcutaneously to elderly

被引：17

作者：

Robelet, Antoine ^{[1
]}

Caruba, Thibaut ^{[1
]}

Corvol, Aline ^{[2
]}

Begue, Dominique ^{[1
]}

Gisselbrecht, Mathilde ^{[2
]}

Saint-Jean, Olivier ^{[2
]}

Prognon, Patrice ^{[1
]}

Sabatier, Brigitte ^{[1
]}

机构：

[1] HEGP, Serv Pharm, F-75015 Paris, France

[2] HEGP, Serv Geriatrie, F-75015 Paris, France

来源：

PRESSE MEDICALE | 2009年 / 38卷 / 03期

关键词：

CUTANEOUS NECROSIS; ILL PATIENTS; CANCER PAIN; PHARMACOKINETICS; HYPODERMOCLYSIS; INFUSION; INJECTIONS; NETILMICIN; GENTAMICIN; GERIATRICS;

D O I：

10.1016/j.lpm.2008.07.018

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim > To find out data of antibiotics efficiency and tolerance given subcutaneously (SC) to elderly. Method > A literature review based on subcutaneous route of antibiotic has been done in PubMed (R) and Cochrane Library (R). Results > Seventeen studies about ten antibiotics have been selected. According to HAS recommendations, methodology of these articles is poor: 3 are level B ond 14 level C. Only amikacin, ceftriaxon ond thiamphenicol have an official mention about SC route. Our literature review indicates that other antibiotics hove been injected by SC route sometimes with local complication: gentamicin, netilmicin, tobramycin, sisomicin, cefepim, ampicillin, teicoplanin and ertapenem. Aminoside SC administration seems to be contra-indicated in clinical practice because of skin necrosis. However for other antibiotics, studies reveal poor evidence-based medicine ond non specific geriatric patient inclusion. For these reasons, SC route for elderly isn't recommended. Conclusion > Antibiotics given SC are little documented despite the great interest for elderly. Reasons of administration are often non official mention engaging prescriber responsibility.

引用

页码：366 / 376

页数：11

共 33 条

[1]

[Anonymous], GUID AN LITT GRAD RE

[2]

BABINET P, 1976, NOUV PRESSE MED, V5, P2640

[3] SAFETY, TOLERANCE, AND PHARMACOKINETICS OF CEFEPIME ADMINISTERED INTRAMUSCULARLY TO HEALTHY-SUBJECTS [J].