Thiohydantoin nucleosides. Synthesis approaches

被引：20

作者：

Khodair, AIA

El Ashry, ESH

Al-Masoudi, NAL

机构：

[1] Tanta Univ, Kafr El Sheikh Branch, Fac Educ, Dept Chem, Kafr Al Sheikh, Egypt

[2] Univ Alexandria, Fac Sci, Dept Chem, Alexandria, Egypt

[3] Univ Konstanz, Dept Chem, D-78457 Constance, Germany

来源：

MONATSHEFTE FUR CHEMIE | 2004年 / 135卷 / 09期

关键词：

biological activity; glycosylation; sugar derivatives; pyrimidines; hydantoin and thiohydantoin nucleosides;

D O I：

10.1007/s00706-004-0194-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several thiohydantoin N-nucleosides and their S-glycosides were prepared via different approaches which involved the direct glycosylation of the free thiohydantoin bases or their silylated derivatives with the corresponding sugar moieties in the presence of base or Lewis acid. Deprotection was carried out in acidic or basic medium. The site of N- and/or S-glycosylation was determined by NMR and UV measurements. In similar manner, hydantoin nucleosides were prepared.

引用

页码：1061 / 1079

页数：19

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