Impact of young age on platinum response in women with epithelial ovarian cancer: Results of a large single-institution registry

Objective. In young women, EOC is a rare disease with an uncertain genetic and biological substrate. Methods. We report a long follow-up of EOC patients treated at Gustave Roussy between 1990 and 2009. We matched young patients aged <= 30 years to randomly selected older patients aged >= 40 years according to known prognostic factors (i.e. FIGO stage, histology and surgical residual disease) and the date of diagnosis with a threshold at the year 2000 to balance the treatment procedures. Results. EOC was diagnosed in 68 patients aged <= 30 years matched with 111 patients aged >= 40 years. Low-grade (LG) (i.e. serous and endometrioid) (52%, n = 35) and mucinous (i.e. 23%, n = 16 infiltrative and 12% n = 8 expansile) tumors are prevalent. High-grade (HG) tumors are rare (7%, n - 5). Early stage diseases (53%, n = 36 FIGO I/II) are predominant. Response to platinum based chemotherapy is observed to be inferior in young patients as compared to matched older patients (ORR, 29 vs 84% p = 0.0002). For HG tumors the PFS is of 0% at 5 and 10 years in younger as compared to 30% in older patients. No difference in PFS (median 4.9 vs 9.8 ms, p = 0.58) and OS (not reached vs 15.3 ms, p = 0.47) is found overall among younger and older patients respectively.The median follow-up was 72 months (range, 11-288 months). No genetic abnormalities were found. Conclusions. Young EOC patients are most often diagnosed at an early FIGO stage with LG serous or mucinous histology. Tumors are significantly more resistant to platinum-based chemotherapy in younger patients. (C) 2020 Elsevier Inc. All rights reserved.