The role of macrophages in the resolution of inflammation

被引：654
作者：
Watanabe, Satoshi [1 ,2 ]
Alexander, Michael [1 ]
Misharin, Alexander V. [1 ]
Budinger, G. R. Scott [1 ]
机构：
[1] Northwestern Univ, Div Pulm & Crit Care Med, Feinberg Sch Med, 240 East Huron St,Room M324, Chicago, IL 60611 USA
[2] Kanazawa Univ, Grad Sch Med Sci, Dept Resp Med, Kanazawa, Ishikawa, Japan
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2019年 / 129卷 / 07期
关键词：
RESIDENT CARDIAC MACROPHAGES; LY6C(HI) MONOCYTES; RECRUITED MACROPHAGES; ALVEOLAR MACROPHAGES; GRANULOMA-FORMATION; CCR2(+) MONOCYTES; ANALYSIS REVEALS; FETAL MONOCYTES; EFFECTOR-CELLS; STEADY-STATE;
D O I：
10.1172/JCI124615
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity, normal tissue development, homeostasis, and repair of damaged tissue. Macrophage function is a sum of their ontogeny, the local environment in which they reside, and the type of injuries or pathogen to which they are exposed. In this Review, we discuss the role of macrophages in the restoration of tissue function after injury, highlighting important questions about how they respond to and modify the local microenvironment to restore homeostasis.
引用
收藏
页码：2619 / 2628
页数：10
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