Autophagy and neurodegeneration

被引：30

作者：

He, Congcong

Klionsky, Daniel J. ^{[1
]}

机构：

[1] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Mol Cellular & Dev Biol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA

来源：

ACS CHEMICAL BIOLOGY | 2006年 / 1卷 / 04期

关键词：

D O I：

10.1021/cb600182h

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autophagy mediates the bulk degradation of cytosolic proteins and organelles. Recent studies using neuron-specific knockout mouse models demonstrate that autophagy deficiency leads to protein aggregation and neurodegeneration, even in the absence of disease-related aggregate-prone proteins.

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收藏

页码：211 / 213

页数：3

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