Clinical and Molecular Relationships between COVID-19 and Feline Infectious Peritonitis (FIP)

被引：13

作者：

Sweet, Arjun N. ^{[1
,2
,3
]}

Andre, Nicole M. ^{[1
,2
]}

Stout, Alison E. ^{[1
,2
]}

Licitra, Beth N. ^{[1
,2
]}

Whittaker, Gary R. ^{[1
,2
]}

机构：

[1] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA

[2] Cornell Univ, Feline Hlth Ctr, Coll Vet Med, Ithaca, NY 14853 USA

[3] Cornell Univ, Coll Human Ecol, Div Nutr Sci, Ithaca, NY 14853 USA

来源：

VIRUSES-BASEL | 2022年 / 14卷 / 03期

关键词：

feline infectious peritonitis; SARS-CoV-2; COVID-19; cats; RESPIRATORY SYNDROME CORONAVIRUS; ANTIBODY-DEPENDENT ENHANCEMENT; POLYMERASE-CHAIN-REACTION; CUTANEOUS LESIONS; SPIKE PROTEIN; PERICARDIAL-EFFUSION; IMMUNE-RESPONSES; CLEAVAGE SITE; CATS; SARS-COV-2;

D O I：

10.3390/v14030481

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The emergence of severe acute respiratory syndrome 2 (SARS-CoV-2) has led the medical and scientific community to address questions surrounding the pathogenesis and clinical presentation of COVID-19; however, relevant clinical models outside of humans are still lacking. In felines, a ubiquitous coronavirus, described as feline coronavirus (FCoV), can present as feline infectious peritonitis (FIP)-a leading cause of mortality in young cats that is characterized as a severe, systemic inflammation. The diverse extrapulmonary signs of FIP and rapidly progressive disease course, coupled with a closely related etiologic agent, present a degree of overlap with COVID-19. This paper will explore the molecular and clinical relationships between FIP and COVID-19. While key differences between the two syndromes exist, these similarities support further examination of feline coronaviruses as a naturally occurring clinical model for coronavirus disease in humans.

引用

页数：23

共 235 条

[1]

Abdul-Rasool Sahar, 2010, Open Virol J, V4, P76, DOI 10.2174/1874357901004010076

[2] Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 [J].