Angiogenesis:: How a tumor adapts to hypoxia

被引：178

作者：

Richard, DE ^{[1
]}

Berra, E ^{[1
]}

Pouysségur, J ^{[1
]}

机构：

[1] Ctr Antoine Lacassagne, UMR CNRS 6543, Inst Signaling Dev Biol & Canc Res, F-06189 Nice, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1999年 / 266卷 / 03期

关键词：

D O I：

10.1006/bbrc.1999.1889

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The growth of new blood vessels from the preexisting vascular tree, also known as angiogenesis, occurs in situations such as wound and fracture healing, arthritis, cardiovascular and cerebral ischemia, and nearly every type of cancer known. Vascular endothelial growth factor (VEGF) has been shown to play a crucial role in these events. Hypoxia-dependent VEGF induction is mediated by hypoxia-inducible factor-1 (HIF-1). HIF-1 is a heterodimeric transcription factor tightly regulated by oxygen concentration. In this short review, we summarize recent data concerning the control of HIF-1 activity and notably the regulation of HIF-1 alpha subunit by phosphorylation and the ubiquitin proteasomal degradation system. A complete knowledge of this mechanism could, by the design of new antiangiogenic strategies, have a strong impact in clinical oncology. (C) 1999 Academic Press.

引用

页码：718 / 722

页数：5

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