Recent Advances in Nanoparticle-Based Cancer Drug and Gene Delivery

被引：215

作者：

Amreddy, Narsireddy ^{[1
,2
]}

Babu, Anish ^{[1
,2
]}

Muralidharan, Ranganayaki ^{[1
,2
]}

Panneerselvam, Janani ^{[1
,2
]}

Srivastava, Akhil ^{[1
,2
]}

Ahmed, Rebaz ^{[1
,3
]}

Mehta, Meghna ^{[1
,2
]}

Munshi, Anupama ^{[1
,2
]}

Ramesh, Rajagopal ^{[1
,2
,3
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Stephenson Canc Ctr, Oklahoma City, OK 73104 USA

[3] Univ Oklahoma, Hlth Sci Ctr, Grad Program Biomed Sci, Oklahoma City, OK 73104 USA

来源：

ADVANCES IN CANCER RESEARCH, VOL 137 | 2018年 / 137卷

关键词：

SOLID LIPID NANOPARTICLES; MESOPOROUS SILICA NANOPARTICLES; SMALL-MOLECULE INHIBITORS; IRON-OXIDE NANOPARTICLES; DOUBLE-STRANDED-RNA; NEAR-INFRARED DYE; CO-DELIVERY; PHOTODYNAMIC THERAPY; IN-VITRO; TARGETED DELIVERY;

D O I：

10.1016/bs.acr.2017.11.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Effective and safe delivery of anticancer agents is among the major challenges in cancer therapy. The majority of anticancer agents are toxic to normal cells, have poor bioavailability, and lack in vivo stability. Recent advancements in nanotechnology provide safe and efficient drug delivery systems for successful delivery of anticancer agents via nanoparticles. The physicochemical and functional properties of the nanoparticle vary for each of these anticancer agents, including chemotherapeutics, nucleic acid-based therapeutics, small molecule inhibitors, and photodynamic agents. The characteristics of the anticancer agents influence the design and development of nanoparticle carriers. This review focuses on strategies of nanoparticle-based drug delivery for various anticancer agents. Recent advancements in the field are also highlighted, with suitable examples from our own research efforts and from the literature.

引用

页码：115 / 170

页数：56

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