The transition from ductal carcinoma in situ to invasive breast cancer: the other side of the coin

被引：42
作者：
Schnitt, Stuart J. [1 ]
机构：
[1] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA
来源：
BREAST CANCER RESEARCH | 2009年 / 11卷 / 01期
关键词：
MYOEPITHELIAL CELLS; TUMOR PROGRESSION; EXPRESSION; STROMA;
D O I：
10.1186/bcr2228
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The factors associated with the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer are poorly understood. Many studies of this subject focus on the role of molecular and genetic alterations in the neoplastic epithelial cells. However, emerging evidence suggests that transition from DCIS to invasive cancer is strongly dependent upon alterations in the microenvironment. The potential roles of myoepithelial cells and of stromal-epithelial interaction are of particular interest in this regard.
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