Benign and malignant portal vein thrombosis: Differentiation by CT characteristics

被引:187
作者
Tublin, ME [1 ]
Dodd, GD [1 ]
Baron, RL [1 ]
机构
[1] UNIV PITTSBURGH,MED CTR,DEPT RADIOL,PITTSBURGH,PA 15213
关键词
D O I
10.2214/ajr.168.3.9057522
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
OBJECTIVE. The purpose of this study was to determine if unique characteristics revealed by CT can allow radiologists to reliably distinguish benign from malignant portal vein thrombus (PVT) in patients with cirrhosis. MATERIALS AND METHODS. CT examinations of 58 patients with cirrhosis and PVT were retrospectively reviewed. Images were assessed for location, extent, enhancement, neovascularity, and maximal diameter of PVT. The type of PVT was proven histologically in 42 patients and clinically in the remaining 16 patients. Using different threshold PVT diameters or the presence of PVT neovascularity, we calculated the sensitivity and specificity of CT for revealing malignant PVT. RESULTS. Forty-seven patients had malignant and 11 patients had benign PVT. CT scans of patients with malignant PVT showed direct extension of hepatocellular carcinoma into the portal vein in 15 patients. In 29 patients with malignant PVT, CT scans showed PVT adjacent to tumor; CT scans showed tumor PVT remote from hepatocellular carcinoma in the remaining three patients with malignant PVT. The mean diameters of malignant and benign portal vein thrombi were significantly different (23.4 mm versus 16 mm; p =.0001). CT scans of 83% (39/47) of patients with malignant PVT and 18% (2/11) of patients with benign PVT showed generalized enhancement. Neovascularity was seen on CT scans in 43% (20/47) of patients with malignant PVT and in no patient with benign PVT. Identification of a main PVT diameter greater than or equal to 23 mm or PVT neovascularity resulted in a sensitivity and specificity for the CT characterization of malignant PVT of 86% and 100%, respectively. CONCLUSION. Malignant and benign thrombi can often be differentiated by radiologists on the basis of CT imaging characteristics.
引用
收藏
页码:719 / 723
页数:5
相关论文
共 31 条
[1]   Hepatocellular carcinoma: Evaluation with biphasic, contrast-enhanced, helical CT [J].
Baron, RL ;
Oliver, JH ;
Dodd, GD ;
Nalesnik, M ;
Holbert, BL ;
Carr, B .
RADIOLOGY, 1996, 199 (02) :505-511
[2]   PORTAL-VEIN THROMBOSIS IN PATIENTS WITH CIRRHOSIS - DOES SONOGRAPHIC DETECTION OF INTRATHROMBUS FLOW ALLOW DIFFERENTIATION OF BENIGN AND MALIGNANT THROMBUS [J].
DODD, GD ;
MEMEL, DS ;
BARON, RL ;
EICHNER, L ;
SANTIGUIDA, LA .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1995, 165 (03) :573-577
[3]   PERCUTANEOUS BIOPSY OF PORTAL-VEIN THROMBUS - A NEW STAGING TECHNIQUE FOR HEPATOCELLULAR-CARCINOMA [J].
DODD, GD ;
CARR, BI .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1993, 161 (02) :229-233
[4]   DETECTION OF MALIGNANT-TUMORS IN END-STAGE CIRRHOTIC LIVERS - EFFICACY OF SONOGRAPHY AS A SCREENING TECHNIQUE [J].
DODD, GD ;
MILLER, WJ ;
BARON, RL ;
SKOLNICK, ML ;
CAMPBELL, WL .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1992, 159 (04) :727-733
[6]   DIAGNOSIS OF PORTAL-VEIN TUMOR THROMBUS BY PULSED DOPPLER ULTRASONOGRAPHY [J].
FURUSE, J ;
MATSUTANI, S ;
YOSHIKAWA, M ;
EBARA, M ;
SAISHO, H ;
TSUCHIYA, Y ;
OHTO, M .
JOURNAL OF CLINICAL ULTRASOUND, 1992, 20 (07) :439-446
[7]   TUMOR THROMBUS IN THE BRANCHES OF THE DISTAL PORTAL-VEIN - CT DEMONSTRATION [J].
IMAEDA, T ;
YAMAWAKI, Y ;
HIROTA, K ;
SUZUKI, M ;
SEKI, M ;
DOI, H .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1989, 13 (02) :262-268
[8]   PERSONAL-EXPERIENCE WITH 411 HEPATIC RESECTIONS [J].
IWATSUKI, S ;
STARZL, TE .
ANNALS OF SURGERY, 1988, 208 (04) :421-434
[9]   HEPATOCELLULAR-CARCINOMA - ASSESSMENT OF RESECTABILITY BY COMPUTED-TOMOGRAPHY AND ULTRASOUND [J].
LABERGE, JM ;
LAING, FC ;
FEDERLE, MP ;
JEFFREY, RB ;
LIM, RC .
RADIOLOGY, 1984, 152 (02) :485-490
[10]   PORTAL-VEIN THROMBOSIS AFTER PERCUTANEOUS ETHANOL INJECTION FOR HEPATOCELLULAR-CARCINOMA - VALUE OF COLOR DOPPLER SONOGRAPHY IN DISTINGUISHING CHEMICAL AND TUMOR THROMBI [J].
LENCIONI, R ;
CARAMELLA, D ;
SANGUINETTI, F ;
BATTOLLA, L ;
FALASCHI, F ;
BARTOLOZZI, C .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1995, 164 (05) :1125-1130