Effect of β-sitosterol on the curcumin-loaded liposomes: Vesicle characteristics, physicochemical stability, in vitro release and bioavailability

被引：111
作者：
Tai, Kedong [1 ]
Rappolt, Michael [2 ]
He, Xiaoye [1 ]
Wei, Yang [1 ]
Zhu, Shaoxin [3 ]
Zhang, Jingbo [3 ]
Mao, Like [1 ]
Gao, Yanxiang [1 ]
Yuan, Fang [1 ]
机构：
[1] China Agr Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing Lab Food Qual & Safety, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China
[2] Univ Leeds, Sch Food Sci & Nutr, Leeds LS2 9JT, W Yorkshire, England
[3] Guangdong Sino Nutrifood Biol Technol Co Ltd, Dongguan 523000, Peoples R China
来源：
FOOD CHEMISTRY | 2019年 / 293卷
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
Liposomes; beta-Sitosterol; Curcumin; Vesicle stability; Release profile; COATED LIPOSOMES; STEROL DERIVATIVES; DELIVERY-SYSTEMS; PLANT STEROLS; DRUG-RELEASE; CHITOSAN; CHOLESTEROL; PERMEABILITY; TEMPERATURE; ABSORPTION;
D O I：
10.1016/j.foodchem.2019.04.077
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In this work, the effect of beta-sitosterol (Sito) on vesicle characteristics, physicochemical stability as well as the in vitro release and bioavailability of curcumin-loaded liposomes (Cur-LP) was studied. When 20-33 mol% of Sito was incorporated, encapsulation efficiency of curcumin was improved due to the high amount of liquid-ordered domains in membranes. At 50 mol% Sito a lower encapsulation efficiency was observed possibly due to membrane defects. The physical, thermal and photo stability of curcumin in liposomes were markedly improved with increasing the amount of Sito. First-order kinetics fitted best the curcumin release dynamics of Sito containing liposomes, clearly showing that sustained release improved with increasing amounts of Sito in liposomes. Simulated digestion studies suggested that Sito concentration of about 20-33 mol% improved the bioavailability of curcumin in liposomes. These study shows that Sito is an applicable and potential route in forming healthier cholesterol-free curcumin-loaded liposomes for functional supplements.
引用
收藏
页码：92 / 102
页数：11
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