Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain

被引：21

作者：

Parkhouse, Rhiannon ^{[1
]}

Boyle, Joseph P. ^{[1
]}

Mayle, Sophie ^{[1
]}

Sawmynaden, Kovilen ^{[2
]}

Rittinger, Katrin ^{[2
]}

Monie, Tom P. ^{[1
,3
]}

机构：

[1] Univ Cambridge, Dept Biochem, Cambridge CB3 0ES, England

[2] Natl Inst Med Res, MRC, Div Mol Struct, London NW7 1AA, England

[3] Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England

来源：

FEBS LETTERS | 2014年 / 588卷 / 17期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

Nucleotide-binding leucine-rich repeat containing receptor; Crohn's Disease; Caspase activation and recruitment domain; Stress kinase pathway; Innate immunity; Signal transduction; MURAMYL DIPEPTIDE RECOGNITION; INFLAMMATORY-BOWEL-DISEASE; ADAPTER PROTEIN CARD9; NF-KAPPA-B; INNATE IMMUNITY; PLASMA-MEMBRANE; CROHNS-DISEASE; ACTIVATION; CELLS; SUSCEPTIBILITY;

D O I：

10.1016/j.febslet.2014.06.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NOD2 activation by muramyl dipeptide causes a proinflammatory immune response in which the adaptor protein CARD9 works synergistically with NOD2 to drive p38 and c-Jun N-terminal kinase (JNK) signalling. To date the nature of the interaction between NOD2 and CARD9 remains undetermined. Here we show that this interaction is not mediated by the CARDs of NOD2 and CARD9 as previously suggested, but that NOD2 possesses two interaction sites for CARD9; one in the CARD-NACHT linker and one in the NACHT itself. Structured summary of protein interactions: NOD2 physically interacts with CARD9 by anti tag coimmunoprecipitation (View interaction) (C) 2014 The Authors. Published by Elsevier B.V.

引用

页码：2830 / 2836

页数：7

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