Synthesis, characterization and DNA binding studies of two mixed ligand complexes of ruthenium(II)

被引：95

作者：

Lawrence, D. ^{[1
]}

Vaidyanathan, V. G. ^{[1
]}

Nair, Balachandran Unni ^{[1
]}

机构：

[1] Cent Leather Res Inst, Chem Lab, Madras 600020, Tamil Nadu, India

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2006年 / 100卷 / 07期

关键词：

Ruthenium(II) complexes; mixed ligand complexes; intercalation; DNA binding;

D O I：

10.1016/j.jinorgbio.2006.02.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two mixed ligand complexes [Ru(bpy)(2)(DMHBT)]Cl-2(1) and [Ru(phen)2(DMHBT)]Cl-2 (2) (where DMHBT is 11,13-dimethyl-13H-4,5,9,11,14-hexaaza-benzo[b]triphenylene-10,12-dione) have been synthesized and characterized by electrospray ionization (ESI) mass, H-1-H-1 correlation spectroscopy (COSY), electronic spectroscopy, fluorescence spectroscopy and cyclic voltammetry. Spectroscopic titration and viscosity changes of calf thymus (CT)-DNA in the presence of incremental amount of complexes I and 2 clearly demonstrate that both these complexes bind intercalatively to DNA, with binding constant 2.87 +/- 0.20 x 10(4)M(-1) and 1.01 +/- 0.20 x 10(5)M(-1) for complexes I and 2, respectively. All the experimental evidences suggest that the ancillary ligand 2,2'-bipyridine (bpy) and 1,10-phenanthroline (phen) influences the intercalative binding of these complexes to DNA. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1244 / 1251

页数：8

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