Non-Urothelial Bladder Cancer: Comparison of Clinicopathological and Prognostic Characteristics in Pure Adenocarcinoma and Non-Bilharzial Squamous Cell Carcinoma of the Bladder

被引：6

作者：

Erdem, Gokmen U. ^{[1
]}

Dogan, Mutlu ^{[2
]}

Sakin, Abdullah ^{[3
]}

Oruc, Zeynep ^{[4
]}

Yaman, Emel ^{[5
]}

Cinkir, Havva Yesil ^{[6
]}

Uysal, Mukremin ^{[7
]}

Bozkurt, Oktay ^{[8
]}

Ozturk, Banu ^{[9
]}

Aytekin, Aydin ^{[10
]}

Ozcelik, Melike ^{[11
]}

Bahceci, Aykut ^{[12
]}

Cakiroglu, Umut ^{[13
]}

Turhal, Serdar ^{[14
]}

Sahin, Suleyman ^{[15
]}

Uncu, Dogan ^{[2
]}

Zengin, Nurullah ^{[2
]}

机构：

[1] Kocaeli Derince Training & Res Hosp, Dept Med Oncol, TR-41310 Ssk Hst, Kocaeli, Turkey

[2] Ankara Numune Training & Res Hosp, Dept Med Oncol, Ankara, Turkey

[3] Okmeydani Training & Res Hosp, Dept Med Oncol, Istanbul, Turkey

[4] Dicle Univ, Fac Med, Dept Med Oncol, Diyarbakir, Turkey

[5] Mersin Univ, Fac Med, Dept Med Oncol, Mersin, Turkey

[6] Dr Abdurrahman Yurtaslan Ankara Oncol Training &, Dept Med Oncol, Ankara, Turkey

[7] Afyon Kocatepe Univ, Fac Med, Dept Med Oncol, Afyon, Turkey

[8] Erciyes Univ, Fac Med, Dept Med Oncol, Kayseri, Turkey

[9] Antalya Training & Res Hosp, Dept Med Oncol, Antalya, Turkey

[10] Gazi Univ, Fac Med, Dept Med Oncol, Ankara, Turkey

[11] Kartal Educ & Res Hosp, Dept Med Oncol, Istanbul, Turkey

[12] Cumhuriyet Univ, Fac Med, Dept Med Oncol, Sivas, Turkey

[13] Pamukkale Univ, Fac Med, Dept Med Oncol, Denizli, Turkey

[14] Anadolu Med Ctr, Dept Med Oncol, Kocaeli, Turkey

[15] Diskapi Yildirim Beyazit Educ & Training Hosp, Dept Med Oncol, Ankara, Turkey

来源：

ONCOLOGY RESEARCH AND TREATMENT | 2018年 / 41卷 / 04期

关键词：

Non-urothelial; Bladder cancer; Adenocarcinoma; Squamous cell carcinoma; URINARY-BLADDER; RADICAL CYSTECTOMY; OUTCOMES;

D O I：

10.1159/000486598

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objectives: The clinicopathological characteristics, treatment modalities, and effects on the prognosis of pure squamous cell carcinoma (SqCC) and adenocarcinoma (AC) were evaluated. Materials and Methods: 86 patients with pure SqCC and AC bladder cancer were evaluated retrospectively. Results: Of the 86 patients, 51 had SqCC and 35 had AC. No differences in clinicopathological characteristics were observed between patients with AC and SqCC, except for the prevalence of T4 disease (28.6% vs. 51.0%, respectively). In multivariate analysis, older age, stage IV disease, and Eastern Cooperative Oncology Group (ECOG) performance status (> 2) were predictive of a poor overall survival (OS). The median OS was significantly longer for stage I-III patients (82.9 months) treated with surgery +/- chemotherapy (CT) +/- radiotherapy (RT) than for those treated with transurethral resection +/- CT +/- RT (24.3 months) (P = 0.007). The median OS of patients with SqCC and AC who were given platinum-based CT for metastasis was 7.7 and 30.3 months, respectively. Conclusions: Advanced age, stage IV disease, and poor ECOG performance status were factors associated with a poor prognosis. Surgery +/- CT +/- RT resulted in significantly better OS, except in stage IV disease. Patients with metastatic AC had better response rates with platinum- based CT. (c) 2018 S. Karger GmbH, Freiburg

引用

页码：220 / 225

页数：6

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