Sonodynamic Therapy Suppresses Neovascularization in Atherosclerotic Plaques via Macrophage Apoptosis-Induced Endothelial Cell Apoptosis

被引：41

作者：

Yao, Jianting ^{[1
]}

Gao, Weiwei ^{[1
]}

Wang, Yu ^{[1
]}

Wang, Lu ^{[1
]}

Diabakte, Kamal ^{[1
]}

Li, Jinyang ^{[2
,3
,4
]}

Yang, Jiemei ^{[1
]}

Jiang, Yongxing ^{[1
]}

Liu, Yuerong ^{[1
]}

Guo, Shuyuan ^{[1
]}

Zhao, Xuezhu ^{[1
]}

Cao, Zhengyu ^{[1
]}

Chen, Xi ^{[1
]}

Li, Qiannan ^{[1
]}

Zhang, Haiyu ^{[1
]}

Wang, Wei ^{[1
]}

Tian, Zhen ^{[2
,3
,4
]}

Li, Bicheng ^{[1
]}

Tian, Fang ^{[1
]}

Wu, Guodong ^{[1
]}

Pourteymour, Shirin ^{[5
]}

Huang, Xi ^{[1
]}

Tan, Fancheng ^{[2
,3
,4
]}

Cao, Xiaoru ^{[2
,3
,4
]}

Yang, Zhuowen ^{[1
]}

Li, Kang ^{[6
]}

Zhang, Yan ^{[7
]}

Li, Yong ^{[8
]}

Zhang, Zhiguo ^{[9
,10
]}

Jin, Hong ^{[5
]}

Tian, Ye ^{[1
,2
,3
,4
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 1, Cardiovasc Inst, Dept Cardiol, 23 Youzheng St, Harbin 150001, Peoples R China

[2] Harbin Med Univ, Dept Pathophysiol, Harbin, Peoples R China

[3] Harbin Med Univ, Key Lab Cardiovasc Pathophysiol, Harbin, Peoples R China

[4] Harbin Med Univ, Minist Educ, Key Lab Cardiovasc Med Res, Harbin, Peoples R China

[5] Karolinska Inst, Dept Med, Stockholm, Sweden

[6] Harbin Med Univ, Dept Epidemiol & Biostat, Harbin, Peoples R China

[7] Harbin Inst Technol, Sch Life Sci & Technol, Res Ctr Computat Biol, Harbin, Peoples R China

[8] Harbin Med Univ, Dept Positron Emiss Tomog Computed Tomog, Affiliated Hosp 1, Harbin, Peoples R China

[9] Harbin Inst Technol, Lab Photo & SonoTheranost Technol, Harbin, Peoples R China

[10] Harbin Inst Technol, Condensed Matter Sci & Technol Inst, Harbin, Peoples R China

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2020年 / 5卷 / 01期

基金：

瑞典研究理事会;

关键词：

apoptosis-induced apoptosis; atherosclerotic plaque; endothelial cell; macrophage; neovascularization; sonodynamic therapy; TRANSCRIPTION FACTOR SP1; INHIBITION; ANGIOGENESIS; INFLAMMATION; PROGRESSION; CLEAVAGE;

D O I：

10.1016/j.jacbts.2019.10.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

During atherosclerosis plaque progression, pathological intraplaque angiogenesis leads to plaque rupture accompanied by thrombosis, which is probably the most important cause of arteries complications such as cerebral and myocardial infarction. Even though few treatments are available to mitigate plaque rupture, further investigation is required to develop a robust optimized therapeutic method. In this study using rabbit and mouse atherosclerotic models, sinoporphyrin sodium (DVDMS)-mediated sonodynamic therapy reduced abnormal angiogenesis and plaque rupture. Briefly, DVDMS is injected to animals, and then the plaque was locally exposed to pulse ultrasound for a few minutes. Furthermore, a small size clinical trial was conducted on patients with atherosclerosis. Notably, a significant reduction of arterial inflammation and angiogenesis was recorded following a short period of DVDMS-mediated sonodynamic therapy treatment. This beneficial outcome was almost equivalent to the therapeutic outcome after 3-month intensive statin treatment. (C) 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：53 / 65

页数：13

共 24 条

[1] Hypoxia-Inducible Factor-1 Expression in Macrophages Promotes Development of Atherosclerosis
Aarup, Annemarie
Pedersen, Tanja X.
Junker, Nanna
Christoffersen, Christina
Bartels, Emil D.
Madsen, Marie
Nielsen, Carsten H.
Nielsen, Lars B.
[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2016, 36 (09) : 1782 - 1790
[2] Do Plaques Rapidly Progress Prior to Myocardial Infarction? The Interplay Between Plaque Vulnerability and Progression
Ahmadi, Amir
Leipsic, Jonathon
Blankstein, Ron
Taylor, Carolyn
Hecht, Harvey
Stone, Gregg W.
Narula, Jagat
[J]. CIRCULATION RESEARCH, 2015, 117 (01) : 99 - 104
[3] Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
Benjamin, LE
Golijanin, D
Itin, A
Pode, D
Keshet, E
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (02) : 159 - 165
[4] Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction
Fantin, Alessandro
Vieira, Joaquim M.
Gestri, Gaia
Denti, Laura
Schwarz, Quenten
Prykhozhij, Sergey
Peri, Francesca
Wilson, Stephen W.
Ruhrberg, Christiana
[J]. BLOOD, 2010, 116 (05) : 829 - 840
[5] Angiogenesis as a therapeutic target
Ferrara, N
Kerbel, RS
[J]. NATURE, 2005, 438 (7070) : 967 - 974
[6] Targeting VEGF-A to treat cancer and age-related macular degeneration
Ferrara, Napoleone
Mass, Robert D.
Campa, Claudio
Kim, Robert
[J]. ANNUAL REVIEW OF MEDICINE, 2007, 58 : 491 - 504
[7] Ten years of anti-vascular endothelial growth factor therapy
Ferrara, Napoleone
Adamis, Anthony P.
[J]. NATURE REVIEWS DRUG DISCOVERY, 2016, 15 (06) : 385 - 403
[8] CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis
Guo, Liang
Akahori, Hirokuni
Harari, Emanuel
Smith, Samantha L.
Polavarapu, Rohini
Karmali, Vinit
Otsuka, Fumiyuki
Gannon, Rachel L.
Braumann, Ryan E.
Dickinson, Megan H.
Gupta, Anuj
Jenkins, Audrey L.
Lipinski, Michael J.
Kim, Johoon
Chhour, Peter
de Vries, Paul S.
Jinnouchi, Hiroyuki
Kutys, Robert
Mori, Hiroyoshi
Kutyna, Matthew D.
Torii, Sho
Sakamoto, Atsushi
Choi, Cheol Ung
Cheng, Qi
Grove, Megan L.
Sawan, Mariem A.
Zhang, Yin
Cao, Yihai
Kolodgie, Frank D.
Cormode, David P.
Arking, Dan E.
Boerwinkle, Eric
Morrison, Alanna C.
Erdmann, Jeanette
Sotoodehnia, Nona
Virmani, Renu
Finn, Aloke V.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2018, 128 (03) : 1106 - 1124
[9] Elimination of neoangiogenesis for plaque stabilization - Is there a role for local drug therapy?
Kolodgie, Frank D.
Narula, Jagat
Yuan, Chun
Burke, Allen P.
Finn, Aloke V.
Virmani, Renu
[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (21) : 2093 - 2101
[10] The ever-expanding role of HIF in tumour and stromal biology
LaGory, Edward L.
Giaccia, Amato J.
[J]. NATURE CELL BIOLOGY, 2016, 18 (04) : 356 - 365

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