Hobit and human effector T-cell differentiation: The beginning of a long journey

被引:17
|
作者
Braun, Julian [1 ]
Frentsch, Marco [1 ]
Thiel, Andreas [1 ]
机构
[1] Charite, Berlin Brandenburg Ctr Regenerat Therapies BCRT, Regenerat Immunol & Aging, D-13353 Berlin, Germany
关键词
CD8(+) T cell; Effector cell; Homolog of Blimp-1 in T cells; Human; T-cell differentiation; Transcription factor; MEMORY CD8(+); SELECTIVE EXPRESSION; CYTOMEGALOVIRUS; RECEPTOR; LYMPHOCYTES; EXHAUSTION; INFECTION; SUBSETS; CD4(+); GENES;
D O I
10.1002/eji.201545959
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Besides growing plants, eating a lot, and drinking beer, Tolkien's Hobbits enjoy maintaining a quiet state. Regarding the latter, the name chosen for a recently discovered transcription factor seems to be unintentionally appropriate. The zinc finger protein ZNF683 was originally named Hobit for Homolog of Blimp-1 in T cells. In this issue of the European Journal of Immunology, Braga etal. [Eur. J. Immunol. 2015. 45: 2945-2958] demonstrate that in humans, Hobit is almost exclusively expressed in effector T cells, in particular in quiescent and long-lived effector-type CD8(+) T cells. Hobit may initially appear as another player in the quest for transcription factors guiding T-cell differentiation; the discoveries of T-bet, Eomes, Blimp-1, and others have significantly contributed to our understanding of how this process is tightly regulated. However, Hobit may be specialthe currently available results suggest substantial differences in Hobit's regulatory functions between mice and humans, such as expression patterns and IFN- regulation. And it may turn out that Hobit's function in human T cells is highly adapted to lifelong, periodic challenges with varying, physiological doses of pathogens. Thus, the new study about Hobit in human T cells may be the beginning of a long journey.
引用
收藏
页码:2762 / 2765
页数:4
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