The preparation and properties of 1,1-difluorocyclopropane derivatives

被引：42

作者：

Adekenova, Kymbat S. ^{[1
]}

Wyatt, Peter B. ^{[1
]}

Adekenov, Sergazy M. ^{[2
]}

机构：

[1] Queen Mary Univ London, Sch Biol & Chem Sci, Mile End Rd, London E1 4NS, England

[2] JSC Int Res & Prod Holding Phytochem, Karaganda 100009, Kazakhstan

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 17卷

关键词：

biological activity; cyclopropanation; difluorocyclopropane derivatives; synthesis; GEM-DIFLUOROCYCLOPROPYL KETONES; RING-OPENING REACTIONS; HALOMETHYL METAL-COMPOUNDS; EFFICIENT SYNTHESIS; THERMAL REARRANGEMENT; BUILDING-BLOCKS; DIFLUORINATED CYCLOPROPANES; METHYLENE DERIVATIVES; FLUORINE-COMPOUNDS; LIQUID-CRYSTALS;

D O I：

10.3762/bjoc.17.25

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Recently, the functionalization of organic molecules with fluorine substituents has grown rapidly due to its applications in such fields as medicine, agriculture or materials sciences. The aim of this article is to review the importance of 1,1-difluorocyclopropane derivatives in synthesis. It will examine the role of the fluorine substituents in both ring-forming and ring-opening reactions, as well as methods for obtaining difluorocyclopropanes as single enantiomers. Several examples are provided to highlight the biological importance of this class of compounds.

引用

页码：245 / 272

页数：28

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