Extracellular Vesicles: Subcellular Organelles With the Potential to Spread Cancer Resistance

被引：18

作者：

Ender, Fanny ^{[1
]}

Von Bubnoff, Nikolas ^{[1
]}

Gieseler, Frank ^{[1
]}

机构：

[1] Univ Lubeck, Univ Med Ctr Schleswig Holstein UKSH, Clin Hematol & Oncol, Expt Oncol, Ratzeburger Allee 160, D-23538 Lubeck, Germany

来源：

ANTICANCER RESEARCH | 2019年 / 39卷 / 07期

关键词：

Cancer drug resistance; extracellular vesicles; exosomes; ectosomes; microvesicles; sequential centrifugation; review; MYELOID-LEUKEMIA CELLS; MULTIDRUG-RESISTANCE; SIGNALING PATHWAY; MEDIATE TRANSFER; PLASMA-MEMBRANE; P-GLYCOPROTEIN; EXOSOMES; MICROVESICLES; MICROPARTICLES; RELEASE;

D O I：

10.21873/anticanres.13483

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although modern anticancer drugs have made great progress in disease treatment, the occurrence of drug resistance often leads to treatment failure. Understanding the molecular basis of resistance mechanisms is important to determine prognosis and develop strategies for circumvention. In this context, subcellular vesicles released by cancer cells have been identified to mediate cellular resistance by various mechanisms. Such extracellular vesicles (EVs) can be subdivided into exosomes and ectosomes based on their size, cargo, and mechanism of formation. The unveiling of EV-targeted treatment options depends on a sound knowledge on EV biology including biogenesis, release, targeting to recipient cells, and uptake. In this review, we focus on EVs as mediators of cancer drug resistance with a particular emphasis on the distinction of exosomes and ectosomes.

引用

页码：3395 / 3404

页数：10

共 87 条

[1] Extracellular Disposal of Tumor-Suppressor miRs-145 and-34a via Microvesicles and 5-FU Resistance of Human Colon Cancer Cells [J].

Akao, Yukihiro ;

Khoo, Fiona ;

Kumazaki, Minami ;

Shinohara, Haruka ;

Miki, Kohei ;

Yamada, Nami .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15 (01) :1392-1401

[2] Intercellular transfer of the oncogenic receptor EGFrvIII by microvesicles derived from tumour cells [J].

Al-Nedawi, Khalid ;

Meehan, Brian ;

Micallef, Johann ;

Lhotak, Vladimir ;

May, Linda ;

Guha, Abhijit ;

Rak, Janusz .

NATURE CELL BIOLOGY, 2008, 10 (05) :619-U24

[3] Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells [J].

Antonyak, Marc A. ;

Li, Bo ;

Boroughs, Lindsey K. ;

Johnson, Jared L. ;

Druso, Joseph E. ;

Bryant, Kirsten L. ;

Holowka, David A. ;

Cerione, Richard A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (12) :4852-4857

[4] Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3 [J].

Aung, Thiha ;

Chapuy, Bjoern ;

Vogel, Daniel ;

Wenzel, Dirk ;

Oppermann, Martin ;

Lahmann, Marlen ;

Weinhage, Toni ;

Menck, Kerstin ;

Hupfeld, Timo ;

Koch, Raphael ;

Truemper, Lorenz ;

Wulf, Gerald G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (37) :15336-15341

[5] Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells [J].

Bebawy, M. ;

Combes, V. ;

Lee, E. ;

Jaiswal, R. ;

Gong, J. ;

Bonhoure, A. ;

Grau, G. E. R. .

LEUKEMIA, 2009, 23 (09) :1643-1649

[6] GAIP Interacting Protein C-Terminus Regulates Autophagy and Exosome Biogenesis of Pancreatic Cancer through Metabolic Pathways [J].

Bhattacharya, Santanu ;

Pal, Krishnendu ;

Sharma, Anil K. ;

Dutta, Shamit K. ;

Lau, Julie S. ;

Yan, Irene K. ;

Wang, Enfeng ;

Elkhanany, Ahmed ;

Alkharfy, Khalid M. ;

Sanyal, Arunik ;

Patel, Tushar C. ;

Chari, Suresh T. ;

Spaller, Mark R. ;

Mukhopadhyay, Debabrata .

PLOS ONE, 2014, 9 (12)

[7] ALIX and the multivesicular endosome: ALIX in Wonderland [J].

Bissig, Christin ;

Gruenberg, Jean .

TRENDS IN CELL BIOLOGY, 2014, 24 (01) :19-25

[8] Transfer of multidrug resistance among acute myeloid leukemia cells via extracellular vesicles and their microRNA cargo [J].

Bouvy, Celine ;

Wannez, Adeline ;

Laloy, Julie ;

Chatelain, Christian ;

Dogne, Jean-Michel .

LEUKEMIA RESEARCH, 2017, 62 :70-76

[9] Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury [J].

Bruno, Stefania ;

Grange, Cristina ;

Deregibus, Maria Chiara ;

Calogero, Raffaele A. ;

Saviozzi, Silvia ;

Collino, Federica ;

Morando, Laura ;

Busca, Alessandro ;

Falda, Michele ;

Bussolati, Benedetta ;

Tetta, Ciro ;

Camussi, Giovanni .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 20 (05) :1053-1067

[10] MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell-Induced Exosomes Via Distinct Multivesicular Body Pathways [J].

Buschow, Sonja I. ;

Nolte-'t Hoen, Esther N. M. ;

van Niel, Guillaume ;

Pols, Maaike S. ;

ten Broeke, Toine ;

Lauwen, Marjolein ;

Ossendorp, Ferry ;

Melief, Cornelis J. M. ;

Raposo, Graca ;

Wubbolts, Richard ;

Wauben, Marca H. M. ;

Stoorvogel, Willem .

TRAFFIC, 2009, 10 (10) :1528-1542

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