Got a Pen for Allergen Immunotherapy? Lessons from Near-Fatal Anaphylaxis with Pulmonary Edema

被引:1
作者
Prenzel, Freerk [1 ,2 ]
Nissler, Karl [3 ]
Siekmeyer, Manuela [1 ]
vom Hove, Maike [1 ,2 ]
Schleicher, Gudrun [4 ]
Kiess, Wieland [1 ]
Lipek, Tobias [1 ,2 ]
机构
[1] Univ Leipzig, Dept Pediat, Med Ctr, Liebigstr 20a, D-04179 Leipzig, Germany
[2] Leipzig Interdisciplinary Ctr Allergy LICA, Leipzig, Germany
[3] Sana Hosp Leipzig Reg, Dept Pediat, Borna, Germany
[4] Pediat Med Practice, Rotha, Germany
关键词
epinephrine auto-injector; allergen immunotherapy; emergency equipment; house dust mite; EPINEPHRINE; CHILDREN; SAFETY; AUTOINJECTORS; MANAGEMENT;
D O I
10.2147/JAA.S287315
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
On our pediatric intensive care unit, we successfully treated a 10-year-old boy with severe pulmonary edema due to anaphylaxis after his last injection of a 3-year course of allergen immunotherapy (AIT). In view of the severity of the adverse event, we initiated a case analysis with all involved medical professionals. The evaluation revealed delayed administration of epinephrine due to dosing uncertainty and underestimation of severity. Consequently, all involved institutions established epinephrine auto-injectors (EAIs) in their emergency equipment. We suggest providing EAIs in every practice conducting AIT, as well as in pediatric emergency rooms and ambulances. We would like to remind readers of the risk of anaphylaxis, even on the last day of AIT.
引用
收藏
页码:753 / 756
页数:4
相关论文
共 27 条
[1]   Pediatric Medication Safety in the Emergency Department [J].
Benjamin, Lee ;
Frush, Karen ;
Shaw, Kathy ;
Shook, Joan E. ;
Snow, Sally K. .
PEDIATRICS, 2018, 141 (03)
[2]   Safety of allergen immunotherapy in North America from 2008-2017: Lessons learned from the ACAAI/AAAAI National Surveillance Study of adverse reactions to allergen immunotherapy [J].
Bernstein, David, I ;
Epstein, Tolly E. G. .
ALLERGY AND ASTHMA PROCEEDINGS, 2020, 41 (02) :108-111
[3]   Autoinjectors Preferred for Intramuscular Epinephrine in Anaphylaxis and Allergic Reactions [J].
Campbell, Ronna L. ;
Bellolio, M. Fernanda ;
Motosue, Megan S. ;
Sunga, Kharmene L. ;
Lohse, Christine M. ;
Rudis, Maria I. .
WESTERN JOURNAL OF EMERGENCY MEDICINE, 2016, 17 (06) :775-782
[4]   HYPOVOLEMIA AND PERMEABILITY PULMONARY-EDEMA ASSOCIATED WITH ANAPHYLAXIS [J].
CARLSON, RW ;
SCHAEFFER, RC ;
PURI, VK ;
BRENNAN, AP ;
WEIL, MH .
CRITICAL CARE MEDICINE, 1981, 9 (12) :883-885
[5]   Epinephrine Auto-Injector Versus Drawn Up Epinephrine for Anaphylaxis Management: A Scoping Review [J].
Chime, Nnenna O. ;
Riese, Victoria G. ;
Scherzer, Daniel J. ;
Perretta, Julianne S. ;
McNamara, LeAnn ;
Rosen, Michael A. ;
Hunt, Elizabeth A. .
PEDIATRIC CRITICAL CARE MEDICINE, 2017, 18 (08) :764-769
[6]   Allergen immunotherapy: A practice parameter third update [J].
Cox, Linda ;
Nelson, Harold ;
Lockey, Richard ;
Calabria, Christopher ;
Chacko, Thomas ;
Finegold, Ira ;
Nelson, Michael ;
Weber, Richard ;
Bernstein, David I. ;
Blessing-Moore, Joann ;
Khan, David A. ;
Lang, David M. ;
Nicklas, Richard A. ;
Oppenheimer, John ;
Portnoy, Jay M. ;
Randolph, Christopher ;
Schuller, Diane E. ;
Spector, Sheldon L. ;
Tilles, Stephen ;
Wallace, Dana .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 127 (01) :S1-S55
[7]   AAAAI/ACAAI Subcutaneous Immunotherapy Surveillance Study (2013-2017): Fatalities, Infections, Delayed Reactions, and Use of Epinephrine Autoinjectors [J].
Epstein, Tolly G. ;
Liss, Gary M. ;
Berendts, Karen Murphy ;
Bernstein, David I. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2019, 7 (06) :1996-+
[8]   Epinephrine in Severe Allergic Reactions: The European Anaphylaxis Register [J].
Grabenhenrich, Linus B. ;
Doelle, Sabine ;
Rueff, Franziska ;
Renaudin, Jean-Marie ;
Scherer, Kathrin ;
Pfoehler, Claudia ;
Treudler, Regina ;
Koehli, Alice ;
Mahler, Vera ;
Spindler, Thomas ;
Lange, Lars ;
Bilo, Maria Beatrice ;
Papadopoulos, Nikolaos G. ;
Hourihane, Jonathan O. B. ;
Lang, Roland ;
Fernandez-Rivas, Montserrat ;
Christoff, George ;
Cichocka-Jarosz, Ewa ;
Worm, Margitta .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2018, 6 (06) :1898-+
[9]   Anaphylaxis in children and adolescents: The European Anaphylaxis Registry [J].
Grabenhenrich, Linus B. ;
Doelle, Sabine ;
Moneret-Vautrin, Anne ;
Koehli, Alice ;
Lange, Lars ;
Spindler, Thomas ;
Rueff, Franziska ;
Nemat, Katja ;
Maris, Ioana ;
Roumpedaki, Eirini ;
Scherer, Kathrin ;
Ott, Hagen ;
Reese, Thomas ;
Mustakov, Tihomir ;
Lang, Roland ;
Fernandez-Rivas, Montserrat ;
Kowalski, Marek L. ;
Bilo, Maria B. ;
Hourihane, Jonathan O'B. ;
Papadopoulos, Nikolaos G. ;
Beyer, Kirsten ;
Muraro, Antonella ;
Worm, Margitta .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2016, 137 (04) :1128-+
[10]   FATAL SYSTEMIC ANAPHYLAXIS IN MAN [J].
JAMES, LP ;
AUSTEN, KF .
NEW ENGLAND JOURNAL OF MEDICINE, 1964, 270 (12) :597-&