DNA interstrand cross-linking by a mycotoxic diepoxide

被引：6

作者：

Millard, JT ^{[1
]}

Katz, JL ^{[1
]}

Goda, J ^{[1
]}

Frederick, ED ^{[1
]}

Pierce, SE ^{[1
]}

Speed, TJ ^{[1
]}

Thamattoor, DM ^{[1
]}

机构：

[1] Colby Coll, Dept Chem, Waterville, ME 04901 USA

来源：

BIOCHIMIE | 2004年 / 86卷 / 06期

关键词：

diepoxybutane; diepoxyoctane; repandiol; DNA interstrand cross-linking;

D O I：

10.1016/j.biochi.2004.03.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The diepoxide mycotoxin (2R, 3R, 8R, 9R)-4,6-decadiyne-2,3:8,9-diepoxy-1,10-diol (repandiol) was both isolated from the mushroom Hydnum repandum and synthesized de novo. Repandiol was found to form interstrand cross-links within a restriction fragment of DNA, linking deoxyuanosines on opposite strands primarily within the 5'-GNC and 5'-GNNC sequences preferred by diepoxyoctane. However, repandiol was a significantly less efficient cross-linker than either of the diepoxyalkanes (diepoxyoctane and diepoxybutane) to which it was compared. (C) 2004 Elsevier SAS. All rights reserved.

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收藏

页码：419 / 423

页数：5

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