Subcutaneous Dermatofibroma of the Cheek

Dermatofibroma, also known as benign fibrous histiocytoma, is a benign tumor composed of fibroblastic and histiocytic cells. Dermatofibroma most frequently occurs in the dermis, but it can also be found in subcutaneous soft tissue in rare cases, particularly on the face. Herein, we report a case of pure subcutaneous dermatofibroma of the cheek, which was confirmed histopathologically with immunohistochemical staining. This report describes a pure subcutaneous dermatofibroma with a literature review and reminds surgeons to consider the possibility that dermatofibromas may occur in the subcutaneous layer before establishing their operative plan.