DNA Repair: A RIDDLE at a Double-Strand Break

被引：7

作者：

Hiom, Kevin ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 0QH, England

来源：

CURRENT BIOLOGY | 2009年 / 19卷 / 08期

基金：

英国医学研究理事会;

关键词：

DAMAGE RESPONSE; BRCA1; TARGETS; CHROMATIN; PROTEINS; LIGASE; SITES; 53BP1; FORM;

D O I：

10.1016/j.cub.2009.03.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ubiquitin is known to accumulate at the sites of DNA damage. The identification of a new ubiquitin ligase, RIDDLIN, provides evidence for a ubiquitin-signalling cascade that regulates the assembly of an important DNA repair complex at a DNA double-strand break.

引用

页码：R331 / R333

页数：3

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