Dual role of histamine on microglia-induced neurodegeneration

被引：48
作者：
Barata-Antunes, S. [1 ]
Cristovao, A. C. [1 ]
Pires, J. [1 ]
Rocha, S. M. [1 ]
Bernardino, L. [1 ]
机构：
[1] Univ Beira Interior, Fac Hlth Sci, Hlth Sci Res Ctr, Covilha, Portugal
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2017年 / 1863卷 / 03期
关键词：
Histamine; Microglia; Lipopolysaccharide; Neuroinflammation; Neurodegeneration; Parkinson's disease; INFLAMMATORY RESPONSE; NEURONAL DEATH; H-3; RECEPTOR; BRAIN; ACTIVATION; LPS; NEUROPROTECTION; TRANSDUCTION; STIMULATION; EXPRESSION;
D O I：
10.1016/j.bbadis.2016.12.016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Several hypotheses have been raised about the dual role of histamine in neurological disorders, and evidences have shown its crucial involvement in the modulation of microglia-mediated neuroinflammation. Previously, we reported that the administration of histamine induces a deleterious effect by promoting a pro-inflammatory phenotype on microglia that in turn compromises dopaminergic neuronal survival. Contrary, under lipopolysaccharide challenge, histamine inhibits the injurious effect of microglia-mediated inflammation, protecting dopaminergic neurons, suggesting that the modulation of microglial activity is dependent on the environmental context. Thus, histamine and/or histamine receptor agonists may serve to develop new therapeutic approaches to overcome neurodegenerative disorders. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：764 / 769
页数：6
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共 50 条
[1]   Histamine production by human neutrophils [J].
Alcaniz, Lorena ;
Vega, Antonio ;
Chacon, Pedro ;
El Bekay, Rajaa ;
Ventura, Inmaculada ;
Aroca, Rocio ;
Blanca, Miguel ;
Bergstralh, Dan T. ;
Monteseirin, Javier .
FASEB JOURNAL, 2013, 27 (07) :2902-2910
[2]   An altered histaminergic innervation of the substantia nigra in Parkinson's disease [J].
Anichtchik, OV ;
Rinne, JO ;
Kalimo, H ;
Panula, P .
EXPERIMENTAL NEUROLOGY, 2000, 163 (01) :20-30
[3]   Toll-Like Receptor 4-Dependent Microglial Activation Mediates Spinal Cord Ischemia-Reperfusion Injury [J].
Bell, Marshall T. ;
Puskas, Ferenc ;
Agoston, Viktor A. ;
Cleveland, Joseph C., Jr. ;
Freeman, Kirsten A. ;
Gamboni, Fabia ;
Herson, Paco S. ;
Meng, Xianzhong ;
Smith, Phillip D. ;
Weyant, Michael J. ;
Fullerton, David A. ;
Reece, T. Brett .
CIRCULATION, 2013, 128 (11) :S152-S156
[4]   Novel Molecular Insights into Classical and Alternative Activation States of Microglia as Revealed by Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-based Proteomics [J].
Bell-Temin, Harris ;
Culver-Cochran, Ashley E. ;
Chaput, Dale ;
Carlson, Christina M. ;
Kuehl, Melanie ;
Burkhardt, Brant R. ;
Bickford, Paula C. ;
Liu, Bin ;
Stevens, Stanley M., Jr. .
MOLECULAR & CELLULAR PROTEOMICS, 2015, 14 (12) :3173-3184
[5]   Histamine in the CNS Multiple functions and potential neurologic implications [J].
Benarroch, Eduardo E. .
NEUROLOGY, 2010, 75 (16) :1472-1479
[6]   The physiology of brain histamine [J].
Brown, RE ;
Stevens, DR ;
Haas, HL .
PROGRESS IN NEUROBIOLOGY, 2001, 63 (06) :637-672
[7]   Neuroinflammation and M2 microglia: the good, the bad, and the inflamed [J].
Cherry, Jonathan D. ;
Olschowka, John A. ;
O'Banion, M. Kerry .
JOURNAL OF NEUROINFLAMMATION, 2014, 11
[8]   Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro [J].
Chhor, Vibol ;
Le Charpentier, Tifenn ;
Lebon, Sophie ;
Ore, Marie-Virgine ;
Celador, Idoia Lara ;
Josserand, Julien ;
Degos, Vincent ;
Jacotot, Etienne ;
Hagberg, Henrik ;
Saevman, Karin ;
Mallard, Carina ;
Gressens, Pierre ;
Fleiss, Bobbi .
BRAIN BEHAVIOR AND IMMUNITY, 2013, 32 :70-85
[9]  
Cristóvao AC, 2009, ANTIOXID REDOX SIGN, V11, P2105, DOI [10.1089/ars.2009.2459, 10.1089/ARS.2009.2459]
[10]   Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration [J].
Cunningham, C ;
Wilcockson, DC ;
Campion, S ;
Lunnon, K ;
Perry, VH .
JOURNAL OF NEUROSCIENCE, 2005, 25 (40) :9275-9284
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