Chronic Infections and Atherosclerosis

被引：46

作者：

Ayada, Kiyoshi ^{[2
]}

Yokota, Kenji ^{[3
]}

Kobayashi, Kazuko ^{[1
]}

Shoenfeld, Yehuda ^{[4
,5
,6
]}

Matsuura, Eiji ^{[1
]}

Oguma, Keiji ^{[2
]}

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cell Chem, Okayama 7008558, Japan

[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Bacteriol, Okayama 7008558, Japan

[3] Okayama Univ, Grad Sch Hlth Sci, Okayama 7008558, Japan

[4] Chaim Sheba Med Ctr, Dept Med B, IL-52621 Tel Hashomer, Israel

[5] Chaim Sheba Med Ctr, Ctr Autoimmune Dis, IL-52621 Tel Hashomer, Israel

[6] Tel Aviv Univ, Incumbent Laura Schwarz Kipp Chair Res Autoimmune, IL-69978 Tel Aviv, Israel

来源：

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY | 2009年 / 37卷 / 01期

关键词：

Atherosclerosis; Heat shock protein 60; Helicobacter pylori; HEAT-SHOCK-PROTEIN; HELICOBACTER-PYLORI INFECTION; CHLAMYDIA-PNEUMONIAE INFECTION; T-CELL-CLONES; SERUM ANTIBODIES; CAROTID ATHEROSCLEROSIS; ENDOTHELIAL-CELLS; IMMUNE-RESPONSES; RISK-FACTORS; MYOCARDIAL-INFARCTION;

D O I：

10.1007/s12016-008-8097-7

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The immune response against heat shock protein 60 (HSP60) derived from pathogens causing chronic infections is thought to be an important pro-atherogenic mechanism because high serum levels of antibodies against HSP60 have been associated with atherosclerotic diseases, such as coronary artery diseases, or cerebro-vascular events. Furthermore, the presence of HSP60-specific T lymphocytes in circulation may increase the risk of atherosclerosis. Our recent in vitro and in vivo studies have also shown an association of Helicobacter pylori-HSP60 (Hp-HSP60) specific Th1 immune responses elicited by H. pylori infection with the progression of atherosclerosis in a hyperlipidemic mouse model. These Th1 dominant immune responses may cross-react with endogenous HSP60 expressed on stressed cells of the vascular endothelium, likely due to molecular mimicry. However, the exact mechanisms by which endothelial cells display their HSP60 molecule or present HSP60 antigenic epitopes on the surface are still unclear.

引用

页码：44 / 48

页数：5

共 45 条

[1]

Amberger A, 1997, CELL STRESS CHAPERON, V2, P94, DOI 10.1379/1466-1268(1997)002<0094:CEOIVE>2.3.CO

[2]

[3] Chronic infections and atherosclerosis [J].

Ayada, Kiyoshi ;

Yokata, Kenji ;

Kobayashi, Kazuko ;

Shoenfeld, Yehuda ;

Matsuura, Eiji ;

Oguma, Keiji .

AUTOIMMUNITY, PT D: AUTOIMMUNE DISEASE, ANNUS MIRABILIS, 2007, 1108 :594-602

[4] Human 60-kDa heat shock protein is a target autoantigen of T cells derived from atherosclerotic plaques [J].

Benagiano, M ;

D'Elios, MM ;

Amedei, A ;

Azzurri, A ;

van der Zee, R ;

Ciervo, A ;

Rombolà, G ;

Romagnani, S ;

Cassone, A ;

Del Prete, G .

JOURNAL OF IMMUNOLOGY, 2005, 174 (10) :6509-6517

[5] T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions [J].

Benagiano, M ;

Azzurri, A ;

Ciervo, A ;

Amedei, A ;

Tamburini, C ;

Ferrari, M ;

Telford, JL ;

Baldari, CT ;

Romagnani, S ;

Cassone, A ;

D'Elios, MM ;

Del Prete, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (11) :6658-6663

[6] Anti-cytomegalovirus (CMV) IgG antibody titer in patients with risk factors to atherosclerosis [J].

Blum, A ;

Peleg, A ;

Weinberg, M .

CLINICAL AND EXPERIMENTAL MEDICINE, 2003, 3 (03) :157-160

[7] THE CRYSTAL-STRUCTURE OF THE BACTERIAL CHAPERONIN GROEL AT 2.8-ANGSTROM [J].

BRAIG, K ;

OTWINOWSKI, Z ;

HEGDE, R ;

BOISVERT, DC ;

JOACHIMIAK, A ;

HORWICH, AL ;

SIGLER, PB .

NATURE, 1994, 371 (6498) :578-586

[8] T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses [J].

Buono, C ;

Binder, CJ ;

Stavrakis, G ;

Witztum, JL ;

Glimcher, LH ;

Lichtman, AH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (05) :1596-1601

[9] Immune responses to heat shock protein in Porphyromonas gingivalis-infected periodontitis and atherosclerosis patients [J].

Chung, SW ;

Kang, HS ;

Park, HR ;

Kim, SJ ;

Choi, JI .

JOURNAL OF PERIODONTAL RESEARCH, 2003, 38 (04) :388-393

[10] Different cytokine profile and antigen-specificity repertoire in Helicobacter pylori-specific T cell clones from the antrum of chronic gastritis patients with or without peptic ulcer [J].

DElios, MM ;

Manghetti, M ;

Almerigogna, F ;

Amedei, A ;

Costa, F ;

Burroni, D ;

Baldari, CT ;

Romagnani, S ;

Telford, JL ;

DelPrete, G .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (07) :1751-1755

← 1 2 3 4 5 →