The blood-brain barrier in psychoneuroimmunology

被引：50
作者：
Banks, William A.
机构：
[1] Vet Affairs Med Ctr St Louis, Ctr Geriatr Res Educ & Clin, St Louis, MO 63106 USA
[2] St Louis Univ, Sch Med, Dept Internal Med, Div Geriatr, St Louis, MO 63103 USA
来源：
NEUROLOGIC CLINICS | 2006年 / 24卷 / 03期
关键词：
D O I：
10.1016/j.ncl.2006.03.009
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The term "psychoneuroimmunology" connotes separate compartments that interact. The blood-brain barrier (BBB) is both the dividing line, physical and physiologic, between the immune system and the central nervous system (CNS) and the locale for interaction. The BBB restricts unregulated mixing of immune substances in the blood with those in the CNS, directly transports neuroimmune-active substances between the blood and CNS, and itself secretes neuroimmune substances. These normal functions of the BBB can be altered by neuroimmune events. As such, the BBB is an important conduit in the communication between the immune system and the CNS.
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页码：413 / +
页数：8
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