Updates on community acquired pneumonia management in the ICU

被引:102
作者
Nair, Girish B. [1 ]
Niederman, Michael S. [2 ]
机构
[1] Oakland Univ, William Beaumont Sch Med, Royal Oak, MI USA
[2] New York Presbyterian Weill Cornell Med Ctr, Weill Cornell Med Coll Pulm & Crit Care, New York, NY USA
关键词
Severe community acquired pneumonia; ATS/IDSA CAP guidelines; New antibiotics; Site of care; CAP severity assessment scores; RESISTANT STAPHYLOCOCCUS-AUREUS; INFECTIOUS-DISEASES-SOCIETY; CELL DISTRIBUTION WIDTH; CRITICALLY-ILL PATIENTS; RISK-FACTORS; STREPTOCOCCUS-PNEUMONIAE; HOSPITALIZED-PATIENTS; DOUBLE-BLIND; PNEUMOCOCCAL PNEUMONIA; ANTIBIOTIC-TREATMENT;
D O I
10.1016/j.pharmthera.2020.107663
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
While the world is grappling with the consequences of a global pandemic related to SARS-CoV-2 causing severe pneumonia, available evidence points to bacterial infection with Streptococcus pneumoniae as the most common cause of severe community acquired pneumonia (SCAP). Rapid diagnostics and molecular testing have improved the identification of co-existent pathogens. However, mortality in patients admitted to ICU remains staggeringly high. The American Thoracic Society and Infectious Diseases Society of America have updated CAP guidelines to help streamline disease management. The common theme is use of timely, appropriate and adequate antibiotic coverage to decrease mortality and avoid drug resistance. Novel antibiotics have been studied for CAP and extend the choice of therapy, particularly for those who are intolerant of, or not responding to standard treatment, including those who harbor drug resistant pathogens. In this review, we focus on the risk factors, microbiology, site of care decisions and treatment of patients with SCAP. (C) 2020 Elsevier Inc. All rights reserved.
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页数:11
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共 103 条
[1]   Initial use of one or two antibiotics for critically ill patients with community-acquired pneumonia: impact on survival and bacterial resistance [J].
Adrie, Christophe ;
Schwebel, Carole ;
Garrouste-Orgeas, Maite ;
Vignoud, Lucile ;
Planquette, Benjamin ;
Azoulay, Elie ;
Kallel, Hatem ;
Darmon, Michael ;
Souweine, Bertrand ;
Anh-Tuan Dinh-Xuan ;
Jamali, Samir ;
Zahar, Jean-Ralph ;
Timsit, Jean-Francois .
CRITICAL CARE, 2013, 17 (06)
[2]   Oral Lefamulin vs Moxifloxacin for Early Clinical Response Among Adults With Community-Acquired Bacterial Pneumonia: The LEAP 2 Randomized Clinical Trial [J].
Alexander, Elizabeth ;
Goldberg, Lisa ;
Das, Anita F. ;
Moran, Gregory J. ;
Sandrock, Christian ;
Gasink, Leanne B. ;
Spera, Patricia ;
Sweeney, Carolyn ;
Paukner, Susanne ;
Wicha, Wolfgang W. ;
Gelone, Steven P. ;
Schranz, Jennifer .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2019, 322 (17) :1661-1671
[3]   Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study [J].
Aliberti, Stefano ;
Reyes, Luis F. ;
Faverio, Paola ;
Sotgiu, Giovanni ;
Dore, Simone ;
Rodriguez, Alejandro H. ;
Soni, Nilam J. ;
Restrepo, Marcos I. .
LANCET INFECTIOUS DISEASES, 2016, 16 (12) :1364-1376
[4]   Managing community acquired pneumonia in the elderly - the next generation of pharmacotherapy on the horizon [J].
Amalakuhan, B. ;
Echevarria, K. L. ;
Restrepo, M. I. .
EXPERT OPINION ON PHARMACOTHERAPY, 2017, 18 (11) :1039-1048
[5]   Impact of guideline-concordant antibiotics and macrolide/-lactam combinations in 3203 patients hospitalized with pneumonia: prospective cohort study [J].
Asadi, L. ;
Eurich, D. T. ;
Gamble, J. M. ;
Minhas-Sandhu, J. K. ;
Marrie, T. J. ;
Majumdar, S. R. .
CLINICAL MICROBIOLOGY AND INFECTION, 2013, 19 (03) :257-264
[6]   Macrolide-Based Regimens and Mortality in Hospitalized Patients With Community-Acquired Pneumonia: A Systematic Review and Meta-analysis [J].
Asadi, Leyla ;
Sligl, Wendy I. ;
Eurich, Dean T. ;
Colmers, Isabelle N. ;
Tjosvold, Lisa ;
Marrie, Thomas J. ;
Majumdar, Sumit R. .
CLINICAL INFECTIOUS DISEASES, 2012, 55 (03) :371-380
[7]   Combination antibiotic therapy lowers mortality among severely ill patients with pneumococcal bacteremia [J].
Baddour, LM ;
Yu, VL ;
Klugman, KP ;
Feldman, C ;
Ortqvist, A ;
Rello, J ;
Morris, AJ ;
Luna, CM ;
Snydman, DR ;
Ko, WC ;
Chedid, MBF ;
Hui, DS ;
Andremont, A ;
Chiou, CCC .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 170 (04) :440-444
[8]   Efficacy and safety of oral solithromycin versus oral moxifloxacin for treatment of community-acquired bacterial pneumonia: a global, double-blind, multicentre, randomised, active-controlled, non-inferiority trial (SOLITAIRE-ORAL) [J].
Barrera, Carlos M. ;
Mykietiuk, Analia ;
Metev, Hristo ;
Nitu, Mimi Floarea ;
Karimjee, Najumuddin ;
Doreski, Pablo Alexis ;
Mitha, Ismail ;
Tanaseanu, Cristina Mihaela ;
Molina, Joseph McDermott ;
Antonovsky, Yuri ;
Van Rensburg, Dirkie Johanna ;
Rowe, Brian H. ;
Flores-Figueroa, Jose ;
Rewerska, Barbara ;
Clark, Kay ;
Keedy, Kara ;
Sheets, Amanda ;
Scott, Drusilla ;
Horwith, Gary ;
Das, Anita F. ;
Jamieson, Brian ;
Fernandes, Prabhavathi ;
Oldach, David .
LANCET INFECTIOUS DISEASES, 2016, 16 (04) :421-430
[9]   Efficacy and Safety of Adjunctive Corticosteroids Therapy for Severe Community-Acquired Pneumonia in Adults: An Updated Systematic Review and Meta-Analysis [J].
Bi, Jirui ;
Yang, Jin ;
Wang, Ying ;
Yao, Cijiang ;
Mei, Jing ;
Liu, Ying ;
Cao, Jiyu ;
Lu, Youjin .
PLOS ONE, 2016, 11 (11)
[10]   Use of procalcitonin to reduce patients' exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial [J].
Bouadma, Lila ;
Luyt, Charles-Edouard ;
Tubach, Florence ;
Cracco, Christophe ;
Alvarez, Antonio ;
Schwebel, Carole ;
Schortgen, Frederique ;
Lasocki, Sigismond ;
Veber, Benoit ;
Dehoux, Monique ;
Bernard, Maguy ;
Pasquet, Blandine ;
Regnier, Bernard ;
Brun-Buisson, Christian ;
Chastre, Jean ;
Wolff, Michel .
LANCET, 2010, 375 (9713) :463-474