Eriodictyol attenuates cisplatin-induced kidney injury by inhibiting oxidative stress and inflammation

被引：68
作者：
Li, Cheng-zhen [1 ,2 ]
Jin, Hai-hong [3 ]
Sun, Hong-xin [2 ]
Zhang, Zhong-zhe [2 ]
Zheng, Jia-xin [4 ]
Li, Shu-hua [4 ]
Han, Seong-ho [1 ]
机构：
[1] Dong A Univ, Coll Med, Dept Family Med, Busan 604714, South Korea
[2] Heilongjiang Prov Hosp, Dept Emergency, Harbin 150000, Peoples R China
[3] Heilongjiang Prov Hosp, Dept Obstet & Gynaecol, Harbin 150000, Peoples R China
[4] Heilongjiang Acad Tradit Chinese Med, Dept Nephrol, Harbin 150000, Peoples R China
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2016年 / 772卷
关键词：
Eriodictyol; Cisplatin; Kidney injury; NF-kappa B; Nrf2; NF-KAPPA-B; INDUCED NEPHROTOXICITY; RENAL INJURY; CELL-DEATH; RATS; APOPTOSIS; EXPRESSION; ACTIVATION; MECHANISM; PROTECTS;
D O I：
10.1016/j.ejphar.2015.12.042
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Eriodictyol, a flavonoid present in citrus fruits, has been reported to have antioxidant and anti-inflammatory effects. In this study, the protective effects of eriodictyol on cisplatin (CP)-induced kidney injury were detected. CP-induced kidney injury model was established by administration of CP (20 mg/ kg). The results showed that treatment of eriodictyol inhibited the production of blood urea nitrogen (BUN), creatinine, MDA, TBARS, reactive oxygen species (ROS), as well as the production of THF-alpha, and IL-1 beta in kidney tissues induced by CP. Eriodictyol also up-regulated the activities of SOD, CAT, and GSH-PX decreased by CP. Furthermore, eriodictyol was found to up-regulate the expression of Nrf2/H0-1 and inhibited CP-induced NE-kappa B activation in kidney tissues. In conclusion, eriodictyol protected against CP-induced kidney injury through activating Nrf2 and inhibiting NE-kappa B activation. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：124 / 130
页数：7
相关论文
共 50 条
  • [21] TAK1 deficiency attenuates cisplatin-induced acute kidney injury
    Zhou, Jun
    An, Changlong
    Jin, Xiaogao
    Hu, Zhaoyong
    Safirstein, Robert L.
    Wang, Yanlin
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2020, 318 (01) : F209 - F215
  • [22] Mangiferin attenuates cisplatin-induced acute kidney injury in rats mediating modulation of MAPK pathway
    Sahu, Anil Kumar
    Verma, Vipin Kumar
    Mutneja, Ekta
    Malik, Salma
    Nag, Tapas Chandra
    Dinda, Amit Kumar
    Arya, Dharamvir Singh
    Bhatia, Jagriti
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2019, 452 (1-2) : 141 - 152
  • [23] Pharmacological Activation of Sirt1 Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing Apoptosis, Oxidative Stress, and Inflammation in Mice
    Kim, Jung-Yeon
    Jo, Jungmin
    Kim, Kiryeong
    An, Hyun-Jin
    Gwon, Mi-Gyeong
    Gu, Hyemin
    Kim, Hyun-Ju
    Yang, A. Young
    Kim, Sung-Woo
    Jeon, Eon Ju
    Park, Jae-Hyung
    Leem, Jaechan
    Park, Kwan-Kyu
    ANTIOXIDANTS, 2019, 8 (08)
  • [24] Renoprotective mechanisms of morin in cisplatin-induced kidney injury
    Wei, Zhengkai
    He, Xuexiu
    Kou, Jinhua
    Wang, Jingjing
    Chen, Libin
    Yao, Minjun
    Zhou, Ershun
    Fu, Yunhe
    Guo, Changming
    Yang, Zhengtao
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2015, 28 (01) : 500 - 506
  • [25] Yishen Jiangzhuo decoction attenuates cisplatin-induced acute kidney injury by inhibiting inflammation, oxidative stress and apoptosis through the TNF signal pathway
    Zheng, Dengyong
    Ruan, Xinglin
    Wu, Qiang
    Qiu, Yuliang
    Ruan, Shiwei
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2024, 28 (02)
  • [26] Chrysophanol Relieves Cisplatin-Induced Nephrotoxicity via Concomitant Inhibition of Oxidative Stress, Apoptosis, and Inflammation
    Ma, Siqing
    Xu, Heng
    Huang, Weihua
    Gao, Yongchao
    Zhou, Honghao
    Li, Xiong
    Zhang, Wei
    FRONTIERS IN PHYSIOLOGY, 2021, 12
  • [27] Protective effects of zingerone on oxidative stress and inflammation in cisplatin-induced rat nephrotoxicity
    Alibakhshi, Tuba
    Khodayar, Mohammad Javad
    Khorsandi, Layasadat
    Rashno, Mohammad
    Zeidooni, Leila
    BIOMEDICINE & PHARMACOTHERAPY, 2018, 105 : 225 - 232
  • [28] S-Allylmercaptocysteine Attenuates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation
    Zhu, Xiaosong
    Jiang, Xiaoyan
    Li, Ang
    Zhao, Zhongxi
    Li, Siying
    NUTRIENTS, 2017, 9 (02):
  • [29] Inhibition of p300 by Garcinol Protects against Cisplatin-Induced Acute Kidney Injury through Suppression of Oxidative Stress, Inflammation, and Tubular Cell Death in Mice
    Kim, Jung-Yeon
    Jo, Jungmin
    Leem, Jaechan
    Park, Kwan-Kyu
    ANTIOXIDANTS, 2020, 9 (12) : 1 - 16
  • [30] Polydatin Attenuates Cisplatin-Induced Acute Kidney Injury by Inhibiting Ferroptosis
    Zhou, Lu
    Yu, Peng
    Wang, Ting-ting
    Du, Yi-wei
    Chen, Yang
    Li, Zhen
    He, Man-lin
    Feng, Lan
    Li, Hui-rong
    Han, Xiao
    Ma, Heng
    Liu, Hong-bao
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2022, 2022
12345