Eriodictyol attenuates cisplatin-induced kidney injury by inhibiting oxidative stress and inflammation

被引：68
|
作者：
Li, Cheng-zhen [1 ,2 ]
Jin, Hai-hong [3 ]
Sun, Hong-xin [2 ]
Zhang, Zhong-zhe [2 ]
Zheng, Jia-xin [4 ]
Li, Shu-hua [4 ]
Han, Seong-ho [1 ]
机构：
[1] Dong A Univ, Coll Med, Dept Family Med, Busan 604714, South Korea
[2] Heilongjiang Prov Hosp, Dept Emergency, Harbin 150000, Peoples R China
[3] Heilongjiang Prov Hosp, Dept Obstet & Gynaecol, Harbin 150000, Peoples R China
[4] Heilongjiang Acad Tradit Chinese Med, Dept Nephrol, Harbin 150000, Peoples R China
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2016年 / 772卷
关键词：
Eriodictyol; Cisplatin; Kidney injury; NF-kappa B; Nrf2; NF-KAPPA-B; INDUCED NEPHROTOXICITY; RENAL INJURY; CELL-DEATH; RATS; APOPTOSIS; EXPRESSION; ACTIVATION; MECHANISM; PROTECTS;
D O I：
10.1016/j.ejphar.2015.12.042
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Eriodictyol, a flavonoid present in citrus fruits, has been reported to have antioxidant and anti-inflammatory effects. In this study, the protective effects of eriodictyol on cisplatin (CP)-induced kidney injury were detected. CP-induced kidney injury model was established by administration of CP (20 mg/ kg). The results showed that treatment of eriodictyol inhibited the production of blood urea nitrogen (BUN), creatinine, MDA, TBARS, reactive oxygen species (ROS), as well as the production of THF-alpha, and IL-1 beta in kidney tissues induced by CP. Eriodictyol also up-regulated the activities of SOD, CAT, and GSH-PX decreased by CP. Furthermore, eriodictyol was found to up-regulate the expression of Nrf2/H0-1 and inhibited CP-induced NE-kappa B activation in kidney tissues. In conclusion, eriodictyol protected against CP-induced kidney injury through activating Nrf2 and inhibiting NE-kappa B activation. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：124 / 130
页数：7
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