Eriodictyol attenuates cisplatin-induced kidney injury by inhibiting oxidative stress and inflammation

被引：69
作者：
Li, Cheng-zhen [1 ,2 ]
Jin, Hai-hong [3 ]
Sun, Hong-xin [2 ]
Zhang, Zhong-zhe [2 ]
Zheng, Jia-xin [4 ]
Li, Shu-hua [4 ]
Han, Seong-ho [1 ]
机构：
[1] Dong A Univ, Coll Med, Dept Family Med, Busan 604714, South Korea
[2] Heilongjiang Prov Hosp, Dept Emergency, Harbin 150000, Peoples R China
[3] Heilongjiang Prov Hosp, Dept Obstet & Gynaecol, Harbin 150000, Peoples R China
[4] Heilongjiang Acad Tradit Chinese Med, Dept Nephrol, Harbin 150000, Peoples R China
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2016年 / 772卷
关键词：
Eriodictyol; Cisplatin; Kidney injury; NF-kappa B; Nrf2; NF-KAPPA-B; INDUCED NEPHROTOXICITY; RENAL INJURY; CELL-DEATH; RATS; APOPTOSIS; EXPRESSION; ACTIVATION; MECHANISM; PROTECTS;
D O I：
10.1016/j.ejphar.2015.12.042
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Eriodictyol, a flavonoid present in citrus fruits, has been reported to have antioxidant and anti-inflammatory effects. In this study, the protective effects of eriodictyol on cisplatin (CP)-induced kidney injury were detected. CP-induced kidney injury model was established by administration of CP (20 mg/ kg). The results showed that treatment of eriodictyol inhibited the production of blood urea nitrogen (BUN), creatinine, MDA, TBARS, reactive oxygen species (ROS), as well as the production of THF-alpha, and IL-1 beta in kidney tissues induced by CP. Eriodictyol also up-regulated the activities of SOD, CAT, and GSH-PX decreased by CP. Furthermore, eriodictyol was found to up-regulate the expression of Nrf2/H0-1 and inhibited CP-induced NE-kappa B activation in kidney tissues. In conclusion, eriodictyol protected against CP-induced kidney injury through activating Nrf2 and inhibiting NE-kappa B activation. (C) 2016 Elsevier B.V. All rights reserved.
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收藏
页码：124 / 130
页数：7
相关论文
共 30 条
[1]   Zingiber officinale Roscoe alone and in combination with α-tocopherol protect the kidney against cisplatin-induced acute renal failure [J].
Ajith, T. A. ;
Nivitha, V. ;
Usha, S. .
FOOD AND CHEMICAL TOXICOLOGY, 2007, 45 (06) :921-927
[2]   Reactive oxygen species: Metabolism, oxidative stress, and signal transduction [J].
Apel, K ;
Hirt, H .
ANNUAL REVIEW OF PLANT BIOLOGY, 2004, 55 :373-399
[3]   Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats [J].
Atessahin, A ;
Yilmaz, S ;
Karahan, I ;
Ceribasi, AO ;
Karaoglu, A .
TOXICOLOGY, 2005, 212 (2-3) :116-123
[4]   The NF-kappa B and I kappa B proteins: New discoveries and insights [J].
Baldwin, AS .
ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :649-683
[5]   NF-κB in Renal Inflammation [J].
Belen Sanz, Ana ;
Dolores Sanchez-Nino, Maria ;
Mario Ramos, Adrian ;
Antonio Moreno, Juan ;
Santamaria, Beatriz ;
Ruiz-Ortega, Marta ;
Egido, Jesus ;
Ortiz, Alberto .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2010, 21 (08) :1254-1262
[6]   Eriodictyol prevents early retinal and plasma abnormalities in streptozotocin-induced diabetic rats [J].
Bucolo, Claudio ;
Leggio, Gian Marco ;
Drago, Filippo ;
Salomone, Salvatore .
BIOCHEMICAL PHARMACOLOGY, 2012, 84 (01) :88-92
[7]   Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity [J].
Chirino, Yolanda I. ;
Pedraza-Chaverri, Jose .
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2009, 61 (03) :223-242
[8]   A New Ferulic Acid Ester and Other Constituents from Dracocephalum pereginum [J].
Dai, Li-Min ;
Zhao, Chun-Chao ;
Jin, Hui-Zi ;
Tang, Jian ;
Shen, Yun-Heng ;
Li, Hui-Liang ;
Peng, Cai-Yun ;
Zhang, Wei-Dong .
ARCHIVES OF PHARMACAL RESEARCH, 2008, 31 (10) :1325-1329
[9]  
Florea Ana-Maria, 2011, Cancers (Basel), V3, P1351, DOI 10.3390/cancers3011351
[10]   Betaine supplementation mitigates cisplatin-induced nephrotoxicity by abrogation of oxidative/nitrosative stress and suppression of inflammation and apoptosis in rats [J].
Hagar, Hanan ;
El Medany, Azza ;
Salam, Reem ;
El Medany, Gamila ;
Nayal, Omina A. .
EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2015, 67 (02) :133-141
123